{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T17:06:27Z","timestamp":1777914387627,"version":"3.51.4"},"reference-count":6,"publisher":"SAGE Publications","issue":"1_part_2","license":[{"start":{"date-parts":[[1989,1,1]],"date-time":"1989-01-01T00:00:00Z","timestamp":599616000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicol Pathol"],"published-print":{"date-parts":[[1989,1]]},"abstract":"<jats:p>The vasculitides consist of a spectrum of clinical syndromes having in common necrotizing inflammation of the vascular system. Typical classification systems are based on both size of vessel involved and clinical gestalt. The author favors a pragmatic classification. Symptoms are manifestations of systemic inflammation and of organ ischemia secondary to inflammatory vascular occlusion. Multicenter studies suggest that the most common vasculitides do not satisfy criteria for one of the specific nosological entities and would be classified as \u201cother\u201d vasculitides. For those syndromes fitting a classical description (e.g., Wegener's, polyarteritis nodosa, Henoch-Schoenlein purpura), therapy is straight-forward. For those defying classification, therapy must be empirically directed at the manifestations causing symptoms.<\/jats:p>","DOI":"10.1177\/019262338901700103","type":"journal-article","created":{"date-parts":[[2017,1,7]],"date-time":"2017-01-07T03:31:19Z","timestamp":1483759879000},"page":"72-76","source":"Crossref","is-referenced-by-count":4,"title":["The Human Vasculitis Syndromes"],"prefix":"10.1177","volume":"17","author":[{"suffix":"Jr.","given":"Robert W.","family":"Lightfoot","sequence":"first","affiliation":[{"name":"University of Kentucky, College of Medicine, Lexington, Kentucky 40536-0084"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1989,1,1]]},"reference":[{"key":"bibr1-019262338901700103","unstructured":"CohenRD ConnDL, and IlstrupDM(1980). Clinical features, prognosis, and response to treatment in polyarteritis. Mayo Clin. Proc. 55: 146\u2013155."},{"key":"bibr2-019262338901700103","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1984.01650400066014"},{"key":"bibr3-019262338901700103","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197908023010503"},{"key":"bibr4-019262338901700103","first-page":"484","volume":"1","author":"Kussmaul A","year":"1866","journal-title":"Dtsch. Arch. Klin. Med."},{"key":"bibr5-019262338901700103","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(86)90186-5"},{"key":"bibr6-019262338901700103","doi-asserted-by":"publisher","DOI":"10.1084\/jem.127.4.819"}],"container-title":["Toxicologic Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/019262338901700103","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/019262338901700103","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T16:50:13Z","timestamp":1777654213000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/019262338901700103"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,1]]},"references-count":6,"journal-issue":{"issue":"1_part_2","published-print":{"date-parts":[[1989,1]]}},"alternative-id":["10.1177\/019262338901700103"],"URL":"https:\/\/doi.org\/10.1177\/019262338901700103","relation":{},"ISSN":["0192-6233","1533-1601"],"issn-type":[{"value":"0192-6233","type":"print"},{"value":"1533-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,1]]}}}