{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T17:07:03Z","timestamp":1777914423909,"version":"3.51.4"},"reference-count":37,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[1990,2,1]],"date-time":"1990-02-01T00:00:00Z","timestamp":633830400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicol Pathol"],"published-print":{"date-parts":[[1990,2]]},"abstract":"<jats:p>\n                    One of the major target organs of hydrogen sulphide gas is the lung. Exfoliation of upper respiratory epithelia and pulmonary edema are prominent effects. Various neuropeptides contained in afferent C-fibres are intimately associated with the epithelia of the conducting airways and are liberated upon exposure to noxious gases. We sought to determine their role in the pathogenesis of hydrogen-sulphide-induced pulmonary injury by pretreating rats with the neurotoxin, capsaicin, which is known to ablate a subpopulation of vagal afferent C-fibres. Groups of capsaicin and saline (control) pretreated Fischer 344 rats were exposed to an edemogenic concentration of hydrogen sulphide (525-559 mg\/rn\n                    <jats:sup>3<\/jats:sup>\n                    ) for 4 hr. Mortality was significantly greater ( p &lt; 0.01) in the capsaicin treated rats (12\/12) compared to the control animals (2\/12). Pulmonary injury was also more severe in the capsaicin pretreated animals as assessed by lung water content, histological grade of pulmonary edema and protein in the broncho-alveolar fluid. Animals depleted of substance P exhibited a significantly greater ( p &lt; 0.01) degree of bronchial epithelial cell exfoliation and ulceration following exposure to hydrogen sulphide. These experiments indicate that capsaicin sensitive sensory nerves may play a major role in pulmonary defense against the effects of inhaled toxic gases such as hydrogen sulphide.\n                  <\/jats:p>","DOI":"10.1177\/019262339001800206","type":"journal-article","created":{"date-parts":[[2009,9,14]],"date-time":"2009-09-14T21:30:11Z","timestamp":1252963811000},"page":"279-288","source":"Crossref","is-referenced-by-count":24,"title":["Capsaicin Pretreatment Modifies Hydrogen Sulphide-Induced Pulmonary Injury in Rats"],"prefix":"10.1177","volume":"18","author":[{"given":"Michael","family":"Prior","sequence":"first","affiliation":[{"name":"Animal Sciences, Alberta Environmental Centre, Vegreville, Alberta, Canada TOB 4L0"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francis","family":"Green","sequence":"additional","affiliation":[{"name":"Respiratory Research Group, Health Sciences Centre, University of Calgary, 3330 Hospital Drive N. W., Calgary, Alberta, Canada T2N 4N1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfonso","family":"Lopez","sequence":"additional","affiliation":[{"name":"Department of Pathology and Microbiology, Atlantic Veterinary College, University of P.E.I., Charlestown, P.E.I., Canada C1A 4P3"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amba","family":"Balu","sequence":"additional","affiliation":[{"name":"Respiratory Research Group, Health Sciences Centre, University of Calgary, 3330 Hospital Drive N. W., Calgary, Alberta, Canada T2N 4N1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George T.","family":"DeSanctis","sequence":"additional","affiliation":[{"name":"Respiratory Research Group, Health Sciences Centre, University of Calgary, 3330 Hospital Drive N. W., Calgary, Alberta, Canada T2N 4N1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gordon","family":"Fick","sequence":"additional","affiliation":[{"name":"Department of Community Health Sciences, University of Calgary, 3330 Hospital Drive N. W., Calgary, Alberta, Canada T2N 4N1"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1990,2,1]]},"reference":[{"key":"atypb1","first-page":"375","volume":"81","author":"Adclson L","year":"1986","journal-title":"Arch. 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