{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T17:07:25Z","timestamp":1777914445240,"version":"3.51.4"},"reference-count":15,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[1991,4,1]],"date-time":"1991-04-01T00:00:00Z","timestamp":670464000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicol Pathol"],"published-print":{"date-parts":[[1991,4]]},"abstract":"<jats:p>Recombinant human interleukin-4 (rhuIL-4) is a candidate for the treatment of refractory cancer based on its potential to enhance the function of the immune system. Total daily dosages of 0 (placebo control), 1,5, or 25 \u03bcg\/kg of rhuIL-4 were given as divided (b.i.d.) subcutaneous dosages to male and female cynomolgus monkeys (5\/sex\/group) for 1 month followed by a 2-week recovery. Histomorphologic evaluation of 3\/sex\/group at 1 month revealed vascular lesions, granulocytic hyperplasia, and seminiferous tubular atrophy attributed to treatment with rhuIL-4. Dosage-dependent proliferative and inflammatory vascular lesions with eosinophil infiltration affected principally the arterial tree. After 2 weeks of recovery, these lesions, including chronic endarteritis and chronic and\/or obliterative arteritis, occurred with an overall lower incidence, and were not observed for monkeys from the 1.0 \u03bcg\/kg\/day group. Granulocytic hyperplasia in bone marrow observed for monkeys from all groups given rhuIL-4 at 1 month was not present after 2 weeks of recovery. Seminiferous tubular atrophy was observed for monkeys from the 5 and 25 \u03bcg\/kg\/day groups at 1 month and after 2 weeks of recovery.<\/jats:p>","DOI":"10.1177\/019262339101900307","type":"journal-article","created":{"date-parts":[[2009,9,14]],"date-time":"2009-09-14T21:30:11Z","timestamp":1252963811000},"page":"251-257","source":"Crossref","is-referenced-by-count":9,"title":["Histomorphologic Observations for Cynomolgus Monkeys after Subchronic Subcutaneous Injection of Recombinant Human Interleukin-4"],"prefix":"10.1177","volume":"19","author":[{"given":"Thomas A.","family":"Barbolt","sequence":"first","affiliation":[{"name":"Department of Toxicology, Sterling Research Group, Rensselaer, New York 12144"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kent A.","family":"Gossett","sequence":"additional","affiliation":[{"name":"Department of Toxicology, Sterling Research Group, Rensselaer, New York 12144"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joel B.","family":"Cornacoff","sequence":"additional","affiliation":[{"name":"Department of Toxicology, Sterling Research Group, Rensselaer, New York 12144"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1991,4,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1988.tb36319.x"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.8670149"},{"key":"atypb3","first-page":"598","volume":"59","author":"Anderson TD","year":"1988","journal-title":"Lab. 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