{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T17:07:22Z","timestamp":1777914442684,"version":"3.51.4"},"reference-count":16,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[1991,4,1]],"date-time":"1991-04-01T00:00:00Z","timestamp":670464000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicol Pathol"],"published-print":{"date-parts":[[1991,4]]},"abstract":"<jats:p>The genotoxic carcinogen vinyl carbamate was dosed to C57B1\/10J strain mice for 35 weeks, and the study terminated after week 59. A main study group of 55 males and 50 females was dosed 6 mg\/kg vinyl carbamate once weekly by intraperitoneal injection, whilst a reference group of 10 animals\/sex were kept undosed. From week 39 onwards there was a high incidence of mortality, which was often associated with acute internal abdominal hemorrhage. Mice of both sexes killed from 34 weeks onwards frequently showed macroscopic evidence of blood-filled, cyst-like structures in the liver. Upon histopathological examination widespread peliosis hepatis was observed with frequent progression to hemangiomata and hemangiosarco-. mata. Trabecular hepatocellular carcinomata were also apparent, often within the same liver sections and invariably associated with peliosis hepatis. As a consequence of its tumor burden, the liver often showed hepatocyte atrophy, fibrosis, and coagulation necrosis. A small number of livers revealed hepatocellular adenomata and altered hepatocyte foci.<\/jats:p>","DOI":"10.1177\/019262339101900308","type":"journal-article","created":{"date-parts":[[2009,9,14]],"date-time":"2009-09-14T21:30:11Z","timestamp":1252963811000},"page":"258-265","source":"Crossref","is-referenced-by-count":3,"title":["Hepatocarcinogenic Effect of Vinyl Carbamate in the C57B1\/10J Strain Mouse"],"prefix":"10.1177","volume":"19","author":[{"given":"Jayne A.","family":"Wright","sequence":"first","affiliation":[{"name":"ICI Pharmaceuticals, Safety of Medicines Department, Mereside, Alderley Park, Macclesfield, Cheshire, SK10 4TG, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan M.","family":"Marsden","sequence":"additional","affiliation":[{"name":"ICI Pharmaceuticals, Safety of Medicines Department, Mereside, Alderley Park, Macclesfield, Cheshire, SK10 4TG, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan M.","family":"Willets","sequence":"additional","affiliation":[{"name":"ICI Pharmaceuticals, Safety of Medicines Department, Mereside, Alderley Park, Macclesfield, Cheshire, SK10 4TG, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Telly C.","family":"Orton","sequence":"additional","affiliation":[{"name":"ICI Pharmaceuticals, Safety of Medicines Department, Mereside, Alderley Park, Macclesfield, Cheshire, SK10 4TG, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1991,4,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/S0016-5085(73)80155-6","volume":"64","author":"Bagheri SA","year":"1973","journal-title":"Gastroenterology"},{"key":"atypb2","first-page":"3793","volume":"38","author":"Dahl GA","year":"1978","journal-title":"Cancer Res."},{"key":"atypb3","first-page":"71","volume":"21","author":"Kawamoto S","year":"1961","journal-title":"Cancer Res."},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1177\/030098588302000404"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/11.3.463"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1016\/0013-9351(74)90040-1"},{"key":"atypb7","first-page":"1359","volume-title":"Cold Spring Harbor Conference on Cell Proliferation","author":"Popper H"},{"key":"atypb8","first-page":"247","volume":"60","author":"Reubner BH","year":"1970","journal-title":"Am. 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