{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T22:58:20Z","timestamp":1785711500858,"version":"3.56.0"},"reference-count":19,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[1992,1,1]],"date-time":"1992-01-01T00:00:00Z","timestamp":694224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicol Pathol"],"published-print":{"date-parts":[[1992,1]]},"abstract":"<jats:p>The relatively high incidence and variety of lesions induced in the upper respiratory tract of rodents by inhalation of xenobiotics has resulted in considerable attention given to the microscopic anatomy of this area. Specific areas of the rodent laryngeal mucosa appear to be more sensitive to inhaled materials and more likely to contain cellular changes in response to injury. These include the epithelium covering the base of the epiglottis, ventral pouch, and the medial surfaces of the vocal processes of the arytenoid cartilages. There are few good landmarks for trimming rodent larynges to get consistent and accurate sections through these target areas. We have obtained consistently reproducible results by cutting transversely through the easily palpable cricothyroid notch and embedding the entire larynx anterior to this in paraffin with the cut surface against the face of the block. Multiple sections are cut from the caudal larynx toward the epiglottis, unstained sections examined microscopically for orientation, and sections from target areas selected for staining and histopathologic examination. Routine use of these methods for preparation and microscopic examination of sections of the larynx has revealed some variations in normal laryngeal anatomy between Fischer 344 (F344\/N) rats and B6C3F1 mice.<\/jats:p>","DOI":"10.1177\/019262339202000106","type":"journal-article","created":{"date-parts":[[2009,4,1]],"date-time":"2009-04-01T19:16:47Z","timestamp":1238613407000},"page":"44-51","source":"Crossref","is-referenced-by-count":42,"title":["Histologic Methods and Interspecies Variations in the Laryngeal Histology of F344\/N Rats and B6C3F1 Mice"],"prefix":"10.1177","volume":"20","author":[{"given":"Roger A.","family":"Renne","sequence":"first","affiliation":[{"name":"Battelle, Pacific Northwest Laboratories, P.O. Box 999, Richland, Washington 99352"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine M.","family":"Gideon","sequence":"additional","affiliation":[{"name":"Battelle, Pacific Northwest Laboratories, P.O. Box 999, Richland, Washington 99352"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodney A.","family":"Miller","sequence":"additional","affiliation":[{"name":"Battelle, Pacific Northwest Laboratories, P.O. Box 999, Richland, Washington 99352"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul W.","family":"Mellick","sequence":"additional","affiliation":[{"name":"Battelle, Pacific Northwest Laboratories, P.O. Box 999, Richland, Washington 99352"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sondra L.","family":"Grumbein","sequence":"additional","affiliation":[{"name":"Battelle, Pacific Northwest Laboratories, P.O. Box 999, Richland, Washington 99352"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[1992,1,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1016\/S0232-1513(89)80082-9"},{"key":"atypb2","first-page":"271","volume":"14","author":"Chevalier HJ","year":"1972","journal-title":"Z Versuchstierk"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-009-3189-3_3"},{"key":"atypb4","first-page":"55","author":"Hebel R.","year":"1976","journal-title":"Baltimore, MD"},{"key":"atypb5","volume-title":"Guide for the Care and Use of Laboratory Animals, NIH Publication No. 78-23","author":"Institute of Laboratory Animal Resources","year":"1978"},{"key":"atypb6","volume-title":"Presented at the meeting of the Oto-Rhino-Laryngological Research Society (ORES), The Royal National Institute of Laryngology and Oncology","author":"Jones TA"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1016\/0378-4274(81)90039-4"},{"key":"atypb8","first-page":"419","volume":"132","author":"Lewis DJ","year":"1981","journal-title":"J. Anat"},{"key":"atypb9","first-page":"617","volume":"130","author":"Lewis DJ","year":"1980","journal-title":"J. Anat"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1080\/15298668291409686"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1159\/000146235"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1159\/000146459"},{"key":"atypb13","volume-title":"General Statement of Work for the Conduct of Toxicity and Carcinogenicity Studies in Laboratory Animals","author":"National Toxicology Program","year":"1987"},{"key":"atypb14","unstructured":"Popp JA, Monteiro-Riviere NA, and Martin JT (1986). Ultrastructure of the rat nasal mucosa. In: Toxicology of the Nasal Passages, CS Barrow (ed), Chemical Industry Institute of Toxicology Series . Hemisphere Publishing Co., Washington, DC, pp. 37-49."},{"key":"atypb15","unstructured":"Reznik G. (1983). Comparative anatomy and histomorphology of the nasal and paranasal cavities in rodents. In: Nasal Tumors in Animals and Man, Vol. 1, Anatomy, Physiology, and Epidemiology, G Reznik and SF Stinson (eds). CRC Press, Boca Raton, FL, pp. 35-44."},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1258\/002367777780936404"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1159\/000212533"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.2307\/3430683"},{"key":"atypb19","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-0590(81)80037-1"}],"container-title":["Toxicologic Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/019262339202000106","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/019262339202000106","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T16:52:22Z","timestamp":1777654342000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/019262339202000106"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,1]]},"references-count":19,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1992,1]]}},"alternative-id":["10.1177\/019262339202000106"],"URL":"https:\/\/doi.org\/10.1177\/019262339202000106","relation":{},"ISSN":["0192-6233","1533-1601"],"issn-type":[{"value":"0192-6233","type":"print"},{"value":"1533-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,1]]}}}