{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T17:07:48Z","timestamp":1777914468099,"version":"3.51.4"},"reference-count":10,"publisher":"SAGE Publications","issue":"3-1","license":[{"start":{"date-parts":[[1992,5,1]],"date-time":"1992-05-01T00:00:00Z","timestamp":704678400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicol Pathol"],"published-print":{"date-parts":[[1992,5]]},"abstract":"<jats:p>Groups of young, sexually mature Fischer-344 rats (n = 25\/sex) obtained from 3 commercial breeders were examined ophthalmologically and histopathologically to determine the prevalence and severity of corneal basement membrane lesions (corneal dystrophy) and basement membrane changes in select nonocular tissues. Results disclosed a high incidence of corneal basement membrane dystrophy in rats of both sexes from all breeders; however, severity levels were significantly increased in rats obtained from one breeder when compared to others. Furthermore, rats that displayed the most advanced corneal lesions also exhibited more severe basement membrane changes in other organs, especially renal tubules and vascular internal laminae. These findings suggest that both ocular and nonocular dystrophic changes may have been linked through common physiologic (or genetic) mechanisms. Animals that displayed basement membrane lesions were not considered to represent compromised biologic test systems.<\/jats:p>","DOI":"10.1177\/019262339202000306","type":"journal-article","created":{"date-parts":[[2009,4,1]],"date-time":"2009-04-01T19:16:47Z","timestamp":1238613407000},"page":"357-366","source":"Crossref","is-referenced-by-count":31,"title":["Spontaneous Corneal Dystrophy and Generalized Basement Membrane Changes in Fischer-344 Rats"],"prefix":"10.1177","volume":"20","author":[{"given":"Richard H.","family":"Bruner","sequence":"first","affiliation":[{"name":"Pathology Associates, Inc., 6217 Centre Park Drive, West Chester, Ohio 45069-3866"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Waldo F.","family":"Keller","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Michigan State University, East Lansing, Michigan 48824"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine A.","family":"Stitzel","sequence":"additional","affiliation":[{"name":"The Procter & Gamble Company, Miami Valley Laboratories, Cincinnati, Ohio 45247"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonard J.","family":"Sauers","sequence":"additional","affiliation":[{"name":"The Procter & Gamble Company, Miami Valley Laboratories, Cincinnati, Ohio 45247"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul J.","family":"Reer","sequence":"additional","affiliation":[{"name":"The Procter & Gamble Company, Miami Valley Laboratories, Cincinnati, Ohio 45247"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip H.","family":"Long","sequence":"additional","affiliation":[{"name":"The Procter & Gamble Company, Winton Hill Technical Center, Cincinnati, Ohio 45224"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert D.","family":"Bruce","sequence":"additional","affiliation":[{"name":"The Procter & Gamble Company, Miami Valley Laboratories, Cincinnati, Ohio 45247"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carl L.","family":"Alden","sequence":"additional","affiliation":[{"name":"The Procter & Gamble Company, Miami Valley Laboratories, Cincinnati, Ohio 45247"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1992,5,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"crossref","unstructured":"Alden CL and Frith CH (1990). The urinary system. In: Handbook of Toxicologic Pathology, WM Haschek and CG Rousseaux (eds). Academic Press, San Diego, pp. 315-387.","DOI":"10.1016\/B978-0-12-330220-5.50020-6"},{"issue":"1","key":"atypb2","first-page":"46","volume":"38","author":"Bellhorn RW","year":"1988","journal-title":"Lab. Anim. Sci"},{"key":"atypb3","first-page":"20","volume":"29","author":"Gibbons JD","year":"1975","journal-title":"Am. Stat"},{"issue":"6","key":"atypb4","first-page":"702","volume":"38","author":"Losco PE","year":"1988","journal-title":"Lab. Anim. Sci"},{"key":"atypb5","unstructured":"National Research Council ( 1978). Guidefor the Care and Use of Laboratory Animals . NIH Publication 78-23, Bethesda, Maryland."},{"key":"atypb6","volume-title":"Statistical Methods","author":"Snedecor GW","year":"1980","edition":"7"},{"key":"atypb7","volume-title":"Abstract. 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Academic Press, New York, pp. 239-259."}],"container-title":["Toxicologic Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/019262339202000306","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/019262339202000306","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T16:52:42Z","timestamp":1777654362000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/019262339202000306"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,5]]},"references-count":10,"journal-issue":{"issue":"3-1","published-print":{"date-parts":[[1992,5]]}},"alternative-id":["10.1177\/019262339202000306"],"URL":"https:\/\/doi.org\/10.1177\/019262339202000306","relation":{},"ISSN":["0192-6233","1533-1601"],"issn-type":[{"value":"0192-6233","type":"print"},{"value":"1533-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,5]]}}}