{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T17:08:38Z","timestamp":1777914518036,"version":"3.51.4"},"reference-count":32,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[1994,7,1]],"date-time":"1994-07-01T00:00:00Z","timestamp":773020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"},{"start":{"date-parts":[[1994,7,1]],"date-time":"1994-07-01T00:00:00Z","timestamp":773020800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Toxicol Pathol"],"published-print":{"date-parts":[[1994,7]]},"abstract":"<jats:p>We attempted to establish an animal model for renal pelvic and ureteral carcinomas. In Experiment 1, Sprague-Dawley (SD)\/cShi and SD\/gShi strains of male and female rats and Fischer-344 (F-344) DuCrj and LEW\/Crj strains of male rats, 6 wk old, were given 0.05% N-butyl- N-(4-hydroxybutyl)nitrosamine (BBN) for 12 wk and then treated without chemical for 10 wk. Only the SD\/cShi strain. which has spontaneous hydronephrosis and hydroureter, showed high incidences of carcinomas in the renal pelvises and ureters, whereas the other strains did not. In Experiment 2, SD\/cShi and Crj:CD strains of male and female rats. 6 wk old, were exposed to 0.05% BBN for 20 wk. Both sexes of SD\/cShi rats had high incidences of bilateral carcinomas in renal pelvises and\/or ureters associated with urinary bladder carcinomas, whereas both sexes of Crj:CD rats had urinary bladder tumors only. These results indicate that the SD\/cShi strain may be a suitable animal for the induction of renal pelvic and ureteral carcinomas that appear to depend on urine stagnation secondary to hydronephrosis and hydroureter.<\/jats:p>","DOI":"10.1177\/019262339402200403","type":"journal-article","created":{"date-parts":[[2009,4,1]],"date-time":"2009-04-01T19:16:47Z","timestamp":1238613407000},"page":"373-380","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Induction of the Renal Peiyic and Ureteral Carcinomas by N-Butyl-N-(4-Hydroxybutyl)nitrosamine in SD\/cShi Rats with Spontaneous Hydronephrosis"],"prefix":"10.1177","volume":"22","author":[{"given":"Satoru","family":"Mori","sequence":"first","affiliation":[{"name":"Aburahi Laboratories, Shionogi & Co., Ltd., Koka-cho, Shiga 520-34, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motoko","family":"Hosono","sequence":"additional","affiliation":[{"name":"Aburahi Laboratories, Shionogi & Co., Ltd., Koka-cho, Shiga 520-34, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Setsuko","family":"Machino","sequence":"additional","affiliation":[{"name":"Aburahi Laboratories, Shionogi & Co., Ltd., Koka-cho, Shiga 520-34, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sachiko","family":"Nakai","sequence":"additional","affiliation":[{"name":"Aburahi Laboratories, Shionogi & Co., Ltd., Koka-cho, Shiga 520-34, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susumu","family":"Makino","sequence":"additional","affiliation":[{"name":"Aburahi Laboratories, Shionogi & Co., Ltd., Koka-cho, Shiga 520-34, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Nakao","sequence":"additional","affiliation":[{"name":"Aburahi Laboratories, Shionogi & Co., Ltd., Koka-cho, Shiga 520-34, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuyoshi","family":"Takeuchi","sequence":"additional","affiliation":[{"name":"Aburahi Laboratories, Shionogi & Co., Ltd., Koka-cho, Shiga 520-34, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reiji","family":"Takeda","sequence":"additional","affiliation":[{"name":"Aburahi Laboratories, Shionogi & Co., Ltd., Koka-cho, Shiga 520-34, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Murai","sequence":"additional","affiliation":[{"name":"First Department of Pathology, Osaka City University Medical School, Asahi-machi, Abeno-ku, Osaka 545, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shoji","family":"Fukushima","sequence":"additional","affiliation":[{"name":"First Department of Pathology, Osaka City University Medical School, Asahi-machi, Abeno-ku, Osaka 545, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1994,7,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19870401)59:7<1369::AID-CNCR2820590724>3.0.CO;2-A"},{"key":"atypb2","first-page":"381","volume":"91","author":"Anderstr\u00f6m C.","year":"1983","journal-title":"Acta Pathol. 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