{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T17:08:41Z","timestamp":1777914521238,"version":"3.51.4"},"reference-count":10,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[1994,9,1]],"date-time":"1994-09-01T00:00:00Z","timestamp":778377600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicol Pathol"],"published-print":{"date-parts":[[1994,9]]},"abstract":"<jats:p>\n                    Pentostatin, an adenosine deaminase inhibitor, has been approved for the treatment of refractory hairy cell leukemia. In a preclinical toxicity study, Wistar rats were administered 0, 1, 10. 25, and 50 mg\/kg (0, 6, 60, 150, and 300 mg\/m\n                    <jats:sup>2<\/jats:sup>\n                    , respectively) pentostatin intravenously once a week for 26 wk (1.5-75-fold above the therapeutic dose in humans). Lymphoplasmacytic thyroiditis was present in 20% of females given 25 mg\/kg and in 20 and 47% of males and females given 50 mg\/kg, respectively. Thyroiditis was still present 4 wk following drug withdrawal. Thyroiditis was characterized by glandular enlargement, follicular epithelial hyperplasia and degeneration, colloid depletion, and interstitial infiltrates of lymphocytes and plasma cells. Drug-related changes in other tissues included lymphoid depletion of T-cell regions of thymus, spleen, and lymph nodes; bronchiolization of alveolar ducts with accumulation of mucus and foamy macrophages; testicular atrophy with sperm granulomas; dermoepidermal lymphocytic infiltrates with ulceration and alopecia; and hepatocytomegaly.\n                  <\/jats:p>","DOI":"10.1177\/019262339402200506","type":"journal-article","created":{"date-parts":[[2009,4,1]],"date-time":"2009-04-01T19:16:47Z","timestamp":1238613407000},"page":"519-523","source":"Crossref","is-referenced-by-count":3,"title":["Subchronic Toxicity of Pentostatin in Wistar Rats"],"prefix":"10.1177","volume":"22","author":[{"given":"Cynthia L.","family":"Courtney","sequence":"first","affiliation":[{"name":"Parke-Davis Pharmaceutical Research, Ann Arbor, Michigan 48105"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathleen L.","family":"Hawkins","sequence":"additional","affiliation":[{"name":"Parke-Davis Pharmaceutical Research, Ann Arbor, Michigan 48105"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles E.","family":"Rothwell","sequence":"additional","affiliation":[{"name":"Parke-Davis Pharmaceutical Research, Ann Arbor, Michigan 48105"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1994,9,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1016\/0008-8749(85)90317-X"},{"key":"atypb2","first-page":"999","volume":"71","author":"Chechik BE","year":"1983","journal-title":"J. Natl. Cancer Inst"},{"key":"atypb3","unstructured":"DeLellis RA (1989). The endocrine system. In: Robbins Pathologic Basis of Disease, 4th ed. RS Cotran, V Kumar , and SL Robbins (eds). W. B. Saunders, Philadelphia , pp. 1220-1222."},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1177\/019262338501300403"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1016\/0300-483X(85)90062-9"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1177\/030098587901600611"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1016\/0090-1229(82)90094-0"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0327(86)90023-6"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4800(85)90031-0"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4684-3300-5_18"}],"container-title":["Toxicologic Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/019262339402200506","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/019262339402200506","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T16:54:26Z","timestamp":1777654466000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/019262339402200506"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,9]]},"references-count":10,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1994,9]]}},"alternative-id":["10.1177\/019262339402200506"],"URL":"https:\/\/doi.org\/10.1177\/019262339402200506","relation":{},"ISSN":["0192-6233","1533-1601"],"issn-type":[{"value":"0192-6233","type":"print"},{"value":"1533-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,9]]}}}