{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T16:40:25Z","timestamp":1777912825097,"version":"3.51.4"},"reference-count":45,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[1996,7,1]],"date-time":"1996-07-01T00:00:00Z","timestamp":836179200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicol Pathol"],"published-print":{"date-parts":[[1996,7]]},"abstract":"<jats:p>\n                    Studies were carried out to test the hypothesis that inflammatory liver disease increases the expression of specific cytochrome P-450 isoenzymes involved in aflatoxin B\n                    <jats:sub>1<\/jats:sub>\n                    (AFB) activation. The immunohistochemical expression and localization of various human cytochrome P-450 isoforms, including CYP2A6, CYP1A2, CYP3A4, and CYP2B1, were examined in normal human liver and liver with hepatitis and cirrhosis. The constitutive expression of CYP3A4 in normal liver showed a characteristic pattern of distribution in centrilobular hepatocytes, whereas CYP1A2, CYP2A6, and CYP2B1 1 were expressed uniformly throughout the liver acinus. In sections of liver infected with hepatitis B virus (HBV) or hepatitis C virus (HCV), the expression of CYP2A6 was markedly increased in hepatocytes immediately adjacent to areas of fibrosis and inflammation. CYP3A4 and CYP2B 1 were induced to a lesser degree, and expression of CYP1A2 was unaffected. In HBV-infected liver, double immunostaining revealed that overexpression of CYP2A6 occurred in hepatocytes expressing the HBV core antigen. In HCV-infected liver, CYP2A6, CYP3A4, and CYP2B 1 were overexpressed in hepatocytes with hemosiderin pigmentation. These results suggest that alterations in phenotypic expression of specific P-450 isoenzymes in hepatocytes associated with hepatic inflammation and cirrhosis might increase susceptibility to AFB genotoxicity.\n                  <\/jats:p>","DOI":"10.1177\/019262339602400408","type":"journal-article","created":{"date-parts":[[2009,4,1]],"date-time":"2009-04-01T19:16:47Z","timestamp":1238613407000},"page":"458-467","source":"Crossref","is-referenced-by-count":47,"title":["Overexpression of Cytochrome P-450 Isoforms Involved in Aflatoxin B1 Bioactivation in Human Liver with Cirrhosis and Hepatitis"],"prefix":"10.1177","volume":"24","author":[{"given":"Gordon M.","family":"Kirby","sequence":"first","affiliation":[{"name":"Lady Davis Institute for Medical Research and Departments of Medicine, Oncology and Pathology, Jewish General Hospital and McGill University, Montreal, Canada H3T 1E2"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerald","family":"Batist","sequence":"additional","affiliation":[{"name":"Lady Davis Institute for Medical Research and Departments of Medicine, Oncology and Pathology, Jewish General Hospital and McGill University, Montreal, Canada H3T 1E2"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lesley","family":"Alpert","sequence":"additional","affiliation":[{"name":"Lady Davis Institute for Medical Research and Departments of Medicine, Oncology and Pathology, Jewish General Hospital and McGill University, Montreal, Canada H3T 1E2"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esther","family":"Lamoureux","sequence":"additional","affiliation":[{"name":"Lady Davis Institute for Medical Research and Departments of Medicine, Oncology and Pathology, Jewish General Hospital and McGill University, Montreal, Canada H3T 1E2"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ross G.","family":"Cameron","sequence":"additional","affiliation":[{"name":"Department of Pathology, Toronto General Hospital, Toronto, Canada M5G 2C4"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moulay A.","family":"Alaoui-Jamali","sequence":"additional","affiliation":[{"name":"Lady Davis Institute for Medical Research and Departments of Medicine, Oncology and Pathology, Jewish General Hospital and McGill University, Montreal, Canada H3T 1E2"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1996,7,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1002\/mc.2940060302"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.12.4790"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1016\/0009-2797(84)90128-5"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)42406-4"},{"key":"atypb5","volume-title":"Arthritis and interleukin-1 stimulate P-450 IV","author":"Batt M.","year":"1990"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(85)90732-4"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(88)90324-4"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/11.2.112"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.19.6909"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/11.8.1293"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/12.2.355"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1002\/mc.2940030104"},{"key":"atypb13","first-page":"89","volume":"9","author":"Fey GH","year":"1990","journal-title":"Prog. 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