{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T06:19:51Z","timestamp":1782281991350,"version":"3.54.5"},"reference-count":44,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[1996,11,1]],"date-time":"1996-11-01T00:00:00Z","timestamp":846806400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicol Pathol"],"published-print":{"date-parts":[[1996,11]]},"abstract":"<jats:p>Japanese medaka (Oryzias latipes) and channel catfish (Ictalurus punctatus) were investigated for carcinogenic response following a 28-day, 3X\/wk pulse exposure to N-methyl- N'-nitro- N-nitrosoguanidine (MNNG). Five-wk-old medaka were exposed at concentrations of 0, 0.5, and 1.0 mg\/L, and 5-mo-old catfish at concentrations of 0, 0.1, and 0.5 mg\/L. In medaka, a total of 19 tumors including 2 branchioblastomas, 6 thyroid follicular adenomas and 1 adenocarcinoma, and 11 subcutaneous fibrosarcomas were observed in 16 of 96 MNNG-exposed fish. In catfish, a total of 37 tumors including 4 squamous cell carcinomas and 16 papillomas, 3 lipomas, 1 fibroma, 1 osteosarcoma, 4 branchioblastomas, 6 thymic epithelial tumors, and 2 generalized lymphosarcomas were observed in 34 of 172 MNNG-exposed fish. The induction of neoplasms in medaka was primarily in the gill, thyroid, and subcutis of the cervical and trunk regions, whereas in catfish skin, thymus, oro-pharynx, and hemopoietic tissues were also commonly affected. In both species, the neoplastic response was considered to be related to direct exposure of the tissues to MNNG. Some of these tumors have not been reported in the literature in either natural or experimental fish. The results also suggest species-specific differences in carcinogenic response following MNNG exposure.<\/jats:p>","DOI":"10.1177\/019262339602400604","type":"journal-article","created":{"date-parts":[[2009,4,1]],"date-time":"2009-04-01T19:16:47Z","timestamp":1238613407000},"page":"696-706","source":"Crossref","is-referenced-by-count":38,"title":["Neoplastic Response in Japanese Medaka and Channel Catfish Exposed to\n                    <i>N<\/i>\n                    -Methyl-\n                    <i>N'<\/i>\n                    -Nitro-\n                    <i>N<\/i>\n                    -Nitrosoguanidine*\n                    <sup>1<\/sup>"],"prefix":"10.1177","volume":"24","author":[{"given":"Hans C.","family":"Chen","sequence":"first","affiliation":[{"name":"National Laboratory Animal Breeding and Research Center, National Science Council, P.O. Box 1-86, Nankang, Taipei 115, Taiwan (ROC)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In J.","family":"Pan","sequence":"additional","affiliation":[{"name":"College of Agriculture and Veterinary Medicine, Nihon University, 1866 Kameino, Fujisawa, Kanagawa 252, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen J.","family":"Tu","sequence":"additional","affiliation":[{"name":"Provincial Research Institute for Animal Health, 376 Chung-cheng Road, Tansui, Taipei 251, Taiwan (ROC)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen H.","family":"Lin","sequence":"additional","affiliation":[{"name":"Provincial Research Institute for Animal Health, 376 Chung-cheng Road, Tansui, Taipei 251, Taiwan (ROC)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chou C.","family":"Hong","sequence":"additional","affiliation":[{"name":"National Laboratory Animal Breeding and Research Center, National Science Council, P.O. Box 1-86, Nankang, Taipei 115, Taiwan (ROC)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mavis R.","family":"Brittelli","sequence":"additional","affiliation":[{"name":"240 Stony Creek Road, Branford, Connecticut 06405, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[1996,11,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/59.6.1747"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1002\/jmor.1051030105"},{"key":"atypb3","first-page":"5675s","volume":"50","author":"Battalora MStJ","year":"1990","journal-title":"Cancer Res"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1577\/1548-8659(1987)116<79:TFACCI>2.0.CO;2"},{"key":"atypb5","first-page":"116","volume":"33","author":"Black JJ","year":"1992","journal-title":"Proc. Am. Assoc. Cancer Res"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/53.3.725"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2761.1985.tb01280.x"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.3354\/dao011117"},{"key":"atypb9","first-page":"3209","volume":"43","author":"Brittelli MR","year":"1985","journal-title":"Cancer Res"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1159\/000398699"},{"key":"atypb11","first-page":"933","volume":"74","author":"Chen HHC","year":"1985","journal-title":"J. Natl. Cancer Inst"},{"key":"atypb12","first-page":"223","volume":"65","author":"Dawe CJ","year":"1984","journal-title":"J. Natl. Cancer Inst. Monogr"},{"key":"atypb13","first-page":"50","volume":"54","author":"Folmer LC","year":"1995","journal-title":"Bull. Environ. Contam. Toxicol"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1577\/1548-8667(1995)007<0178:RAIMTN>2.3.CO;2"},{"key":"atypb15","volume-title":"Anatomy and Histology of the Channel Catfish","author":"Grizzle JM","year":"1976"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2761.1981.tb01142.x"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2761.1990.tb00771.x"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9975(08)80102-8"},{"key":"atypb19","unstructured":"Harshbarger JC (1983). Lung tumors in nondomesticated animals. In: Comparative Respiratory Tract Carcinogenesis, Vol. 1, HM Reznick-Schuller (ed). CRC Press. Boca Raton, Florida, pp. 219-231."},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.1016\/0048-9697(90)90362-X"},{"key":"atypb21","first-page":"243","volume":"52","author":"Hatanaka J.","year":"1982","journal-title":"J. Exp. Med"},{"key":"atypb22","first-page":"453","volume":"76","author":"Hawkins WE","year":"1986","journal-title":"J. Natl. Cancer Inst"},{"key":"atypb23","doi-asserted-by":"publisher","DOI":"10.1002\/jat.2550050408"},{"key":"atypb24","doi-asserted-by":"publisher","DOI":"10.1016\/0166-445X(89)90006-4"},{"key":"atypb25","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/64.6.1511"},{"key":"atypb26","doi-asserted-by":"publisher","DOI":"10.1016\/S1546-5098(08)60317-9"},{"key":"atypb27","first-page":"478","volume":"78","author":"Hyodo-Taguchi Y.","year":"1987","journal-title":"J. Cancer Res. (Gann)"},{"key":"atypb28","unstructured":"International Agency for Research on Cancer (1974). Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Humans, Vol. 4. IARC, Lyon, pp. 183-195."},{"key":"atypb29","volume-title":"MNNG induction of gill tumors in a platyfish X swordtail F1 hybrid in medaka (Oryzias latipes) and nifurpirinol induction of hepatomas in medaka. Annual Report No. 20","author":"Kimura I.","year":"1982"},{"key":"atypb30","first-page":"16","volume":"35","author":"Kimura I.","year":"1976","journal-title":"Proc. Jpn. Cancer Assoc"},{"key":"atypb31","doi-asserted-by":"publisher","DOI":"10.1111\/j.1095-8649.1980.tb03732.x"},{"key":"atypb32","first-page":"1058","volume":"80","author":"Masahito P.","year":"1989","journal-title":"J. Cancer Res"},{"key":"atypb33","doi-asserted-by":"publisher","DOI":"10.7589\/0090-3558-21.1.74"},{"key":"atypb34","first-page":"336","volume":"21","author":"Olen E.","year":"1965","journal-title":"Lab. Invest"},{"key":"atypb35","doi-asserted-by":"publisher","DOI":"10.1016\/0166-445X(88)90076-8"},{"key":"atypb36","doi-asserted-by":"publisher","DOI":"10.1177\/030098589403100102"},{"key":"atypb37","volume-title":"Fish Pathology","author":"Roberts RJ","year":"1980","edition":"2"},{"key":"atypb38","volume-title":"Tumors of the Thymus. Atlas of Tumor Pathology, 2nd ser","author":"Rosai J.","year":"1976"},{"key":"atypb39","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2761.1989.tb00326.x"},{"key":"atypb40","first-page":"215","volume":"31","author":"Steeves III HR","year":"1969","journal-title":"Natl. Cancer Inst. Monogr"},{"key":"atypb41","doi-asserted-by":"publisher","DOI":"10.1159\/000398710"},{"key":"atypb42","first-page":"2994","volume":"49","author":"Torikata C.","year":"1989","journal-title":"Cancer Res"},{"key":"atypb43","first-page":"195","volume":"31","author":"Walker R.","year":"1969","journal-title":"Natl. Cancer Inst. Monogr"},{"key":"atypb44","first-page":"59","volume":"31","author":"Wellings SR","year":"1969","journal-title":"J. Natl. Cancer Inst. Monogr"}],"container-title":["Toxicologic Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/019262339602400604","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/019262339602400604","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T16:05:53Z","timestamp":1777651553000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/019262339602400604"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,11]]},"references-count":44,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1996,11]]}},"alternative-id":["10.1177\/019262339602400604"],"URL":"https:\/\/doi.org\/10.1177\/019262339602400604","relation":{},"ISSN":["0192-6233","1533-1601"],"issn-type":[{"value":"0192-6233","type":"print"},{"value":"1533-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,11]]}}}