{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T19:51:44Z","timestamp":1793476304595,"version":"4.5.0"},"reference-count":23,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[1997,9,1]],"date-time":"1997-09-01T00:00:00Z","timestamp":873072000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicol Pathol"],"published-print":{"date-parts":[[1997,9]]},"abstract":"<jats:p>The toxicity of the plant Rhamnus cathartica was assessed in mice after the plant was identified as a potential cause of an idiopathic neurologic disease in horses. Another member of the Rhamnaceae family, Karwinskia humboldtiana, is neurotoxic to mammals and birds and can induce hepatic degeneration and necrosis. To investigate the toxicity of R. cathartica, a 34-day feeding trial in mice was conducted using a complete rodent diet with 0, 5, or 25% added R. cathartica. No clinical signs or gross lesions were seen, and all major tissues were histologically normal except the liver. The livers of mice fed R. cathartica had marked hepatocellular swelling. Results from periodic acid-Schiff reaction staining and from electron microscopy confirmed that the swelling was due to deposits of monoparticulate glycogen (\u03b2 particles) in the cytoplasm. Glycogen deposition is an uncommon toxic change in cells. Apparently, compound(s) in R. cathartica directly or indirectly interfered with glycogen metabolism (either glycogenesis or glycogenolysis). Mechanistic and chronicity studies with R. cathartica are needed to investigate the pathophysiology of the glycogen disturbance and to determine if hepatic injury progresses and if other organs will be injured.<\/jats:p>","DOI":"10.1177\/019262339702500503","type":"journal-article","created":{"date-parts":[[2009,4,1]],"date-time":"2009-04-01T19:16:47Z","timestamp":1238613407000},"page":"449-452","source":"Crossref","is-referenced-by-count":11,"title":["Rhamnus cathartica (Buckthorn) Hepatocellular Toxicity in Mice"],"prefix":"10.1177","volume":"25","author":[{"given":"Carol A.","family":"Lichtensteiger","sequence":"first","affiliation":[{"name":"Department of Veterinary University of Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy A.","family":"Johnston","sequence":"additional","affiliation":[{"name":"Department of Veterinary Biosciences, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, Illinois 61802"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val R.","family":"Beasley","sequence":"additional","affiliation":[{"name":"Department of Veterinary Biosciences, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, Illinois 61802"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[1997,9,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1981.tb02370.x"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1016\/0041-0101(86)90135-2"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196707132770204"},{"key":"atypb4","first-page":"1381","volume":"32","author":"Charlton K.","year":"1971","journal-title":"Am. J. Vet. Res"},{"key":"atypb5","first-page":"389","volume":"27","author":"Charlton KM","year":"1969","journal-title":"Tex. Rep. Biol. Med"},{"key":"atypb6","first-page":"408","volume":"7","author":"Charlton KM","year":"1970","journal-title":"Distribution of lesions in peripheral nerves. Pathol. Vet"},{"key":"atypb7","first-page":"127","author":"Cheville NF","year":"1994","journal-title":"An Introduction to Interpretation"},{"key":"atypb8","first-page":"51","author":"Cheville NF","year":"1994","journal-title":"An Introduction to Interpretation"},{"key":"atypb9","first-page":"259","author":"Cross PC","year":"1993","journal-title":"A Functional Perspective,"},{"issue":"9","key":"atypb10","first-page":"15","volume":"13","author":"Cummings JF","year":"1991","journal-title":"Equine Pract"},{"key":"atypb11","first-page":"215","volume":"46","author":"Dewan ML","year":"1965","journal-title":"Am. J. Pathol"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1016\/0041-0101(94)90361-1"},{"key":"atypb13","first-page":"659","volume":"50","author":"Hard GC","year":"1984","journal-title":"Lab. Invest"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1016\/0300-483X(87)90062-X"},{"key":"atypb15","doi-asserted-by":"crossref","unstructured":"Jubb KVF and Huxtable CR (1992). The nervous system. In: Pathology of Domestic Animals, 4th ed. KVF Jubb, PC Kennedy , and N Palmer (eds). Academic Press, New York, pp. 267-439.","DOI":"10.1016\/B978-0-08-057133-1.50011-4"},{"key":"atypb16","doi-asserted-by":"crossref","unstructured":"Kingsbury JM (1964). Angiosperms. In: Poisonous Plants of the United States and Canada, JM Kingsbury (ed). Prentice-Hall, Englewood Cliffs, New Jersey, pp. 124-503.","DOI":"10.1097\/00010694-196411000-00022"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-330220-5.50011-5"},{"key":"atypb18","volume-title":"Coyotillo (Karwinskia humboldtiana) as a Poisonous Plant. Technical Bulletin","author":"Marsh CD","year":"1928"},{"key":"atypb19","unstructured":"National Research Council ( 1996). Composition of selected feeds. In: Nutrient Requirements of Beef Cattle, 7th ed. National Academy Press, Washington, D.C., pp. 133-148."},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.1007\/BF02889032"},{"key":"atypb21","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-330220-5.50019-X"},{"key":"atypb22","unstructured":"Sheehan DC and Hrapchak BB (1980). Carbohydrates. In: Theory and Practice of Histotechnology, 2nd ed. DC Sheehan and BB Hrapchak (eds). C. V. Mosby, St. Louis , pp. 159-179."},{"key":"atypb23","first-page":"336","author":"Weller RO","year":"1980","journal-title":"Experimental and Clinical Neurotoxicology"}],"container-title":["Toxicologic Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/019262339702500503","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/019262339702500503","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T16:06:23Z","timestamp":1777651583000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/019262339702500503"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,9]]},"references-count":23,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1997,9]]}},"alternative-id":["10.1177\/019262339702500503"],"URL":"https:\/\/doi.org\/10.1177\/019262339702500503","relation":{},"ISSN":["0192-6233","1533-1601"],"issn-type":[{"value":"0192-6233","type":"print"},{"value":"1533-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,9]]}}}