{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T16:41:05Z","timestamp":1777912865017,"version":"3.51.4"},"reference-count":13,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[1997,11,1]],"date-time":"1997-11-01T00:00:00Z","timestamp":878342400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicol Pathol"],"published-print":{"date-parts":[[1997,11]]},"abstract":"<jats:p>A uterine choriocarcinoma was found in a 49-wk-old virgin Donryu rat given intrauterine administration of N-ethyl-N'-nitro-N-nitrosoguanidine (ENNG) . The tumor was macroscopically present as a bloody cystic mass and microscopically composed of 2 kinds of cells: small basophilic cells similar to cytotrophoblasts in the rat placenta and large cells with big nuclei resembling giant trophoblasts. The giant cells were positive for 3\u03b2-hydroxysteroid dehydrogenase (3\u03b2-HSD), although immunohistochemical examination was negative or nonspecific for chorionic gonadotrophins, including \u03b2 human chorionic gonadotrophin (\u03b2hCG), human placental lactogen (hPL), and placental glycoprotein (SP-1), or for placental alkaline phosphatase (ALP). However, the animal exhibited a slight mammotropic status. The results thus suggest a choriocarcinoma nature for this uterine tumor and that the tumor cells secrete a weakly mammotrophic hormone.<\/jats:p>","DOI":"10.1177\/019262339702500616","type":"journal-article","created":{"date-parts":[[2009,4,1]],"date-time":"2009-04-01T19:16:47Z","timestamp":1238613407000},"page":"644-646","source":"Crossref","is-referenced-by-count":2,"title":["A Uterine Choriocarcinoma in a Virgin Donryu Rat"],"prefix":"10.1177","volume":"25","author":[{"given":"Midori","family":"Yoshida","sequence":"first","affiliation":[{"name":"Department of Pathology, Sasaki Institute, 2-2, Kanda-Surugadai, Chiyoda-ku, Tokyo 101 Japan,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuhisa","family":"Shiraki","sequence":"additional","affiliation":[{"name":"Department of Pathology, Sasaki Institute, 2-2, Kanda-Surugadai, Chiyoda-ku, Tokyo 101 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kayoko","family":"Kudoh","sequence":"additional","affiliation":[{"name":"Department of Pathology, Sasaki Institute, 2-2, Kanda-Surugadai, Chiyoda-ku, Tokyo 101 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Ando-Lu","sequence":"additional","affiliation":[{"name":"Department of Pathology, Sasaki Institute, 2-2, Kanda-Surugadai, Chiyoda-ku, Tokyo 101 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masakazu","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Pathology, Sasaki Institute, 2-2, Kanda-Surugadai, Chiyoda-ku, Tokyo 101 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiko","family":"Maekawa","sequence":"additional","affiliation":[{"name":"Department of Pathology, Sasaki Institute, 2-2, Kanda-Surugadai, Chiyoda-ku, Tokyo 101 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1997,11,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1177\/030098588702400305"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.877391"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1210\/endo-127-6-3131"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1177\/019262339302100112"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1293\/tox.8.435"},{"key":"atypb6","first-page":"255","volume":"39","author":"Madarame H.","year":"1989","journal-title":"Lab. Anim. Sci"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1177\/030098589102800117"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(66)90150-5"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-72550-0_21"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-72550-0_19"},{"key":"atypb11","first-page":"524","volume":"72","author":"Teshima S.","year":"1981","journal-title":"J. Cancer Res"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910440522"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1210\/endo-98-2-505"}],"container-title":["Toxicologic Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/019262339702500616","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/019262339702500616","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T16:06:34Z","timestamp":1777651594000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/019262339702500616"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,11]]},"references-count":13,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1997,11]]}},"alternative-id":["10.1177\/019262339702500616"],"URL":"https:\/\/doi.org\/10.1177\/019262339702500616","relation":{},"ISSN":["0192-6233","1533-1601"],"issn-type":[{"value":"0192-6233","type":"print"},{"value":"1533-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,11]]}}}