{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T16:41:23Z","timestamp":1777912883761,"version":"3.51.4"},"reference-count":17,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[1998,5,1]],"date-time":"1998-05-01T00:00:00Z","timestamp":893980800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicol Pathol"],"published-print":{"date-parts":[[1998,5]]},"abstract":"<jats:p>An adenosine agonist, designated chemically as (R)-N-(2,3-dihydro-lH-inden-1-yl) adenosine or CI-947, was administered orally to 2 males and 2 female cynomolgus monkeys each at 5, 10, 20, and 50 mg\/kg of body weight for 2 wk. One male and 1 female given 50 mg\/kg were euthanatized on days 10 and 8, respectively, because of poor clinical condition. Emesis was present at 10, 20, and 50 mg\/kg. Decreased heart rate and QT prolongation were present at 50 mg\/kg. Extramural coronary arterial lesions consisting of medial necrosis with cellular debris and mixed inflammatory cell response in the intima, media, and adventitia were present in 1 male at 20 mg\/kg and 1 male at 50 mg\/kg at study termination. Similar arterial lesions were present in the small and large intestines and testis of the male at 50 mg\/kg. Colonic mucosal erosions with mixed inflammatory cell infiltrates in the lamina propria were seen in this male and in all CI-947 treated females at 10, 20, and 50 mg\/kg. Myocardial degeneration and necrosis of myocardial fibers with mononuclear cell infiltrates in the interstitium were noted in the left ventricle of 1 female at 20 mg\/kg and in all animals at 50 mg\/kg. Renal cortical tubular dilatation with increases in serum creatinine and\/or blood urea nitrogen were noted in a control female and animals at 10 and 50 mg\/kg. Plasma CI-947 concentration increased with increasing dose. Coronary vascular injury in the monkey was similar to the arterial lesion in CI-947-treated dogs and may relate to the pharmacologic\/hemodynamic effects induced by CI-947. When compared with the dog, the monkey appears to be less sensitive to development of arteriopathy, as indicated by lower incidence, at similar systemic exposure levels.<\/jats:p>","DOI":"10.1177\/019262339802600311","type":"journal-article","created":{"date-parts":[[2009,9,14]],"date-time":"2009-09-14T21:30:11Z","timestamp":1252963811000},"page":"375-380","source":"Crossref","is-referenced-by-count":20,"title":["Arteriopathy Induced by an Adenosine Agonist-Antihypertensive in Monkeys"],"prefix":"10.1177","volume":"26","author":[{"given":"Mudher A.","family":"Albassam","sequence":"first","affiliation":[{"name":"Parke-Davis Research Institute, Mississauga, Ontario, Canada L5K 1B4"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graham S.","family":"Smith","sequence":"additional","affiliation":[{"name":"Parke-Davis Research Institute, Mississauga, Ontario, Canada L5K 1B4"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grace E.","family":"Macallum","sequence":"additional","affiliation":[{"name":"Parke-Davis Research Institute, Mississauga, Ontario, Canada L5K 1B4"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1998,5,1]]},"reference":[{"key":"atypb1","first-page":"628","volume":"43","author":"Albassam MA","year":"1993","journal-title":"Lab. 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