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In the current investigation, the dose-dependent effects of chronic iron toxicosis on heart tissue concentrations of selenium and the protective antioxidant enzyme glutathione peroxidase (GPx) were investigated in a murine model of iron-overload cardiomyopathy (n = 20). Significant dose-dependent decreases in heart tissue selenium concentrations (r =- 0.95, p &lt;0.001) and selenium-dependent GPx activity (r =- 0.93, p &lt;0.001) were observed in chronically iron-loaded mice in comparison with placebo controls. 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