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The aims of the study were to identify symptom-based dysmenorrhea phenotypes and examine their relationships with demographic and clinical characteristics. In a cross-sectional study, 762 women with dysmenorrhea rated severity of 14 dysmenorrhea-related symptoms. Using latent class analysis, we identified three distinctive phenotypes. Women in the \u201cmild localized pain\u201d phenotype ( n = 202, 26.51%) had mild abdominal cramps and dull abdominal pain\/discomfort. Women in the \u201csevere localized pain\u201d phenotype ( n = 412, 54.07%) had severe abdominal cramps. Women in the \u201cmultiple severe symptoms\u201d phenotype ( n = 148, 19.42%) had severe pain at multiple locations and multiple gastrointestinal symptoms. Race, ethnicity, age, and comorbid chronic pain conditions were significantly associated with phenotypes. Identification of these symptom-based phenotypes provides a foundation for research examining genotype\u2013phenotype associations, etiologic mechanisms, and\/or variability in treatment responses.<\/jats:p>","DOI":"10.1177\/0193945917731778","type":"journal-article","created":{"date-parts":[[2017,12,31]],"date-time":"2017-12-31T13:14:16Z","timestamp":1514726056000},"page":"1452-1468","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":32,"title":["Symptoms-Based Phenotypes Among Women With Dysmenorrhea: A Latent Class Analysis"],"prefix":"10.1177","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6902-1227","authenticated-orcid":false,"given":"Chen X.","family":"Chen","sequence":"first","affiliation":[{"name":"Indiana University, Indianapolis, IN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Ofner","sequence":"additional","affiliation":[{"name":"Indiana University, Indianapolis, IN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgos","family":"Bakoyannis","sequence":"additional","affiliation":[{"name":"Indiana University, Indianapolis, IN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristine L.","family":"Kwekkeboom","sequence":"additional","affiliation":[{"name":"University of Wisconsin\u2013Madison, WI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet S.","family":"Carpenter","sequence":"additional","affiliation":[{"name":"Indiana University, Indianapolis, IN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,9,15]]},"reference":[{"key":"bibr1-0193945917731778","doi-asserted-by":"publisher","DOI":"10.1086\/504814"},{"key":"bibr2-0193945917731778","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-015-3855-2"},{"key":"bibr3-0193945917731778","doi-asserted-by":"publisher","DOI":"10.1093\/poq\/nfq048"},{"issue":"3","key":"bibr4-0193945917731778","first-page":"1","volume":"21","author":"Berkley K. 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