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We performed a secondary analysis of the baseline data from a clinical trial including 1,645 individuals with OUD, of which 513 had anxiety disorder. Substance use disorders (SUDs) included alcohol, amphetamines, cannabis, cocaine, and sedative use disorders. Mood disorders included major depressive disorder (MDD) and bipolar disorder (BD). Chronic conditions were allergies, gastrointestinal problem(s), skin problem(s), and hypertension. Sedative use disorder, MDD, BD, skin problems, and hypertension were significantly associated with anxiety disorder ( p\u2009&lt;\u20090.05). Additionally, more than two SUDs, two mood disorders, and more than two chronic conditions were significantly associated with anxiety disorder ( p\u2009&lt;\u20090.05). These findings highlight the comorbid mental health and physical health problems in individuals with OUD, as well as the need for integrated multidisciplinary treatment plans.<\/jats:p>","DOI":"10.1177\/01939459211031988","type":"journal-article","created":{"date-parts":[[2021,7,24]],"date-time":"2021-07-24T02:52:27Z","timestamp":1627095147000},"page":"1088-1099","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Polysubstance Use, Mood Disorders, and Chronic Conditions With Anxiety in Opioid Patients"],"prefix":"10.1177","volume":"44","author":[{"given":"Sophia","family":"Liu","sequence":"first","affiliation":[{"name":"College of Literature, Science, and the Arts, University of Michigan, Ann Arbor, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Nwabueze","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Epidemiology, College of Public Health, East Tennessee State University, Johnson City, TN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences, Miller School of Medicine, University of Miami, Miami, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzy Mascaro","family":"Walter","sequence":"additional","affiliation":[{"name":"Department of Family and Community Health, School of Nursing, Health Sciences Center, West Virginia University, Morgantown, WV, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brenda","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Health and Biomedical Sciences, College of Health Professions, University of Texas Rio Grande Valley, Brownsville, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Health and Biomedical Sciences, College of Health Professions, University of Texas Rio Grande Valley, Brownsville, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin L.","family":"Winstanley","sequence":"additional","affiliation":[{"name":"Department of Behavioral Medicine & Psychiatry, Rockefeller Neuroscience Institute, School of Medicine, West Virginia University, Morgantown, WV, USA"},{"name":"Department of Neurology, West Virginia University, Morgantown, WV, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7118-3877","authenticated-orcid":false,"given":"Kesheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Family and Community Health, School of Nursing, Health Sciences Center, West Virginia University, Morgantown, WV, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,7,23]]},"reference":[{"key":"bibr1-01939459211031988","unstructured":"Aggarwal V., Kosian S. 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