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A latent class analysis was conducted to identify latent subgroups of seriously ill older adults based on a baseline Charlson comorbidity index (CCI) measurement, a measure of comorbidity burden, and mortality risk. The three latent subgroups were: (1) low to moderate CCI with MCC, (2) high CCI with MCC, and (3) high CCI and metastatic cancer. The \u201clow to moderate CCI and MCC\u201d subgroup included older adults with chronic obstructive pulmonary disease (COPD), cardiovascular disease, congestive heart failure, myocardial infarction, dementia, diabetes, and lymphoma. A \u201chigh CCI and MCC\u201d subgroup included individuals with severe illness including liver or renal disease among other MCCs. A \u201chigh CCI and metastatic cancer\u201d included all participants with metastatic cancer. 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