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Pentoxifylline is a methylxanthine derivative that produces dose\u2010related improvement in blood flow, lower blood viscosity, improved erythrocyte flexibility, and increased tissue oxygen levels. An agent that increases blood flow and tissue oxygen content may contribute to enhanced healing of soft tissue pathology. Sixteen adult New Zealand rabbits were separated into 2\u00a0groups and inspected for 30 weeks after radiation. We noted acute and chronic reactions and pathologic changes in different regions of the head and neck of rabbits. The prophylactic administration of pentoxifylline in the postirradiation period can reduce late soft tissue pathology, but it does not affect acute radiation reactions.<\/jats:p>","DOI":"10.1177\/019459980112400614","type":"journal-article","created":{"date-parts":[[2017,7,13]],"date-time":"2017-07-13T14:56:24Z","timestamp":1499957784000},"page":"669-673","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Pentoxifylline Effects on Acute and Late Complications after Radiotherapy in Rabbit"],"prefix":"10.1002","volume":"124","author":[{"given":"Erdinc","family":"Aygenc","sequence":"first","affiliation":[{"name":"Ankara Numune Hospital 2nd ENT Clinic Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serdar","family":"Celikkanat","sequence":"additional","affiliation":[{"name":"Ankara Numune Hospital 2nd ENT Clinic Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hasan","family":"Bilgili","sequence":"additional","affiliation":[{"name":"Veterinary Faculty of Ankara University Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ferdi","family":"Aksaray","sequence":"additional","affiliation":[{"name":"Ankara Numune Hospital Radiation Oncology Department Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sibel","family":"Orhun","sequence":"additional","affiliation":[{"name":"Ankara First Aid and Traffic Hospital Pathology Department Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustafa","family":"Kaymakci","sequence":"additional","affiliation":[{"name":"Ankara Numune Hospital 2nd ENT Clinic Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cafer","family":"Ozdem","sequence":"additional","affiliation":[{"name":"Ankara Numune Hospital 2nd ENT Clinic Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,7,19]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"485","article-title":"Radiotherapy for carcinomas of the head and neck in elderly patients","volume":"172","author":"Huguenin P","year":"1996","journal-title":"Strahlenther Onkol"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(89)90376-3"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1185\/03007998609110431"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1148\/101.2.429"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(77)90010-4"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(93)90027-S"},{"key":"e_1_2_1_8_1","first-page":"996","article-title":"AHFS 95 Drug Information","author":"McEvoy GK","year":"1995","journal-title":"American Hospital Formulary Service"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199703000-00022"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(90)90549-Y"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016489309135795"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00168855"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/019459980112400614","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/019459980112400614","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:36:56Z","timestamp":1760956616000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1177\/019459980112400614"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,6]]},"references-count":11,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2001,6]]}},"alternative-id":["10.1177\/019459980112400614"],"URL":"https:\/\/doi.org\/10.1177\/019459980112400614","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"type":"print","value":"0194-5998"},{"type":"electronic","value":"1097-6817"}],"subject":[],"published":{"date-parts":[[2001,6]]},"assertion":[{"value":"2016-07-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}