{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:38:48Z","timestamp":1761007128020,"version":"build-2065373602"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2011,2,1]],"date-time":"2011-02-01T00:00:00Z","timestamp":1296518400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2011,5]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>(1) To assess the long\u2010term impact of thyroid ala cartilage laryngotracheal reconstruction (TAC\u2010LTR) on health\u2010related quality of life (QOL) in infants using 4 validated instruments: Health Utility Index version 3 (HUI3), Pediatric Voice\u2010Related QOL (PVRQOL), Impact on Family Questionnaire, and a visual analog scale and (2) to perform acoustic and perceptual voice assessments to evaluate long\u2010term voice quality outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Prospective study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Tertiary academic pediatric hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects<\/jats:title><jats:p>Eligible children who received TAC\u2010LTR before the age of 24\u00a0months between 1995 and 2007.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Interviews with parents and children using 4 validated instruments, voice analyses, and endoscopic evaluation were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twelve patients (7\u00a0male, 5 female, median age 10 years) were enrolled over a 6\u2010month period. The mean age at LTR was 5\u00a0months (range, 1\u201020\u00a0months), and the mean study follow\u2010up period was 9 years (range, 2\u201014 years). The average speech HUI3, PVRQOL, and Impact on Family scores were 0.83 (95% confidence interval = 0.74, 0.92), 0.93 (interquartile range [IQR] = 0.81, 1.00), and 0.65 (IQR = 0.54, 0.92), respectively. All acoustic scores were either normal or mildly abnormal for the variables jitter, shimmer, noise\u2010to\u2010harmonic ratio, peak amplitude variation, and fundamental frequency. The Consensus Auditory\u2010Perceptual Evaluation of Voice overall severity score was in the normal to mildly abnormal range for 8 of 9 patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This is the first study to explore and quantify long\u2010term QOL and voice quality in children following LTR with thyroid ala graft at a very young age. Most patients had very good functional voice outcome as evidenced by the HUI3 and PVRQOL scores. This was corroborated by acoustic and perceptual voice assessments.<\/jats:p><\/jats:sec>","DOI":"10.1177\/0194599810391198","type":"journal-article","created":{"date-parts":[[2011,2,2]],"date-time":"2011-02-02T21:13:09Z","timestamp":1296681189000},"page":"770-777","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Quality of Life and Voice Outcomes after Thyroid Ala Graft Laryngotracheal Reconstruction in Young Children"],"prefix":"10.1002","volume":"144","author":[{"given":"Yamilet","family":"Tirado","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery The Hospital for Sick Children University of Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neil K.","family":"Chadha","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery The Hospital for Sick Children University of Toronto 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