{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:05:19Z","timestamp":1787018719927,"version":"build-2736575974"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2011,2,1]],"date-time":"2011-02-01T00:00:00Z","timestamp":1296518400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2011,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To prospectively measure the prevalence and effect of symptomatic depression on chronic rhinosinusitis (CRS) patients\u2019 quality of life (QOL), disease severity, and outcomes of endoscopic sinus surgery (ESS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>Prospective cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Academic, tertiary care center.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Subjects and Methods<\/jats:title>\n                    <jats:p>Seventy\u2010six patients with CRS were enrolled prior to ESS and followed postoperatively for a mean (SD) of 13.3 (5.4) months. Lund\u2010Mackay computed tomography score, Lund\u2010Kennedy endoscopy score, Patient Health Questionnaire\u20139 (PHQ\u20109), 2 disease\u2010specific QOL instruments (Rhinosinusitis Disability Index [RSDI] and Chronic Sinusitis Survey [CSS]), and 1 general QOL instrument (Medical Outcomes Study Short Form\u201336 [SF\u201036]) were measured. Differences in outcome scores were analyzed using univariate and multivariate analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Only 7 (9.2%) patients reported a history of depression, but 19 (25.0%) patients scored in the range of moderate or severe depression on the PHQ\u20109. Mean (SD) preoperative scores were significantly worse in depressed patients on the RSDI (62.7 [18.2] vs 45.3 [16.3];\n                      <jats:italic>P<\/jats:italic>\n                      &lt;. 001) and 7 of 8 SF\u201036 domains (all\n                      <jats:italic>P<\/jats:italic>\n                      \u2264. 011). Patients with depression significantly improved on both disease\u2010specific QOL instruments (mean [SD] change; RSDI: 33.5 [24.7],\n                      <jats:italic>P<\/jats:italic>\n                      =. 017; CSS: 25.0 [20.9],\n                      <jats:italic>P<\/jats:italic>\n                      =. 012) and 3 SF\u201036 domains (all\n                      <jats:italic>P<\/jats:italic>\n                      \u2264. 050). Postoperative change scores were not significantly different from patients without depression on the RSDI, CSS, or SF\u201036. Severity of depression significantly improved postoperatively in depressed patients (preoperative PHQ\u20109 scores: 13.4 [2.0] vs 6.1 [4.5],\n                      <jats:italic>P<\/jats:italic>\n                      =. 017).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>CRS patients with depression had worse baseline QOL than other CRS patients but experienced comparable postoperative improvement in QOL after ESS. Interestingly, depression severity significantly improved after ESS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0194599810391625","type":"journal-article","created":{"date-parts":[[2011,2,2]],"date-time":"2011-02-02T21:13:09Z","timestamp":1296681189000},"page":"446-451","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":73,"title":["Role of Depression in Outcomes of Endoscopic Sinus Surgery"],"prefix":"10.1002","volume":"144","author":[{"given":"Jamie R.","family":"Litvack","sequence":"first","affiliation":[{"name":"Department of Otology and Laryngology Massachusetts Eye &amp; Ear Infirmary Harvard Medical School Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jess","family":"Mace","sequence":"additional","affiliation":[{"name":"Division of Rhinology and Sinus Surgery Oregon Sinus Center Department of Otolaryngology\u2013Head &amp; Neck Surgery Oregon Health &amp; Science University Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy L.","family":"Smith","sequence":"additional","affiliation":[{"name":"Division of Rhinology and Sinus Surgery Oregon Sinus Center Department of Otolaryngology\u2013Head &amp; 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