{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T18:07:08Z","timestamp":1793383628276,"version":"4.5.0"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2011,2,10]],"date-time":"2011-02-10T00:00:00Z","timestamp":1297296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2011,4]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To test the hypothesis that uvulopalatopharyngoplasty (UPPP) improves sleep apnea\u2013related quality of life (measured on the Functional Outcomes of Sleep Questionnaire [FOSQ]) at 3\u2010month follow\u2010up. Secondary objectives were to test (1) the stability of the outcomes at 6\u00a0months, (2) the effect on global sleep apnea quality\u2010of\u2010life change, and (3) the effect on sleep apnea symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Multicenter, prospective, longitudinal case series.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Diverse university\u2010 and community\u2010based otolaryngology practices.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>The cohort included 68 patients from 17 practices, with a mean \u00b1 standard deviation age of 44 \u00b1 12 years and mean apnea\u2010hypopnea index of 35 \u00b1 32 events\/hour. All patients underwent UPPP, defined as an open procedure modifying the shape and size of the palate, pharynx, and uvula, with or without tonsillectomy. Baseline data were collected on site before surgery, and outcome data were collected by mail 3 and 6\u00a0months after surgery, with follow\u2010up rates of 51% and 50%, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>FOSQ scores improved from 14.3 \u00b1 3.4 (scale 5\u201020, normal \u226517.9) at baseline to 17.2 \u00b1 2.7 at 3\u00a0months (mean improvement 2.9; 95% confidence interval, 1.8\u20104.0; <jats:italic>P<\/jats:italic> &lt;. 001) and 17.5 \u00b1 2.5 at 6\u00a0months (mean improvement 3.1; 95% confidence interval, 2.0\u20104.2; <jats:italic>P<\/jats:italic> &lt;. 001). All quality\u2010of\u2010life and symptom measures improved significantly at 3 and 6\u00a0months (all <jats:italic>P<\/jats:italic> &lt;. 05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This prospective, multicenter, university\u2010 and community\u2010based study provides evidence that UPPP significantly improves disease\u2010specific quality of life and sleep apnea symptoms in patients with sleep apnea. Validity may be limited by significant loss to follow\u2010up and absence of an unoperated control group.<\/jats:p><\/jats:sec>","DOI":"10.1177\/0194599810394982","type":"journal-article","created":{"date-parts":[[2011,2,10]],"date-time":"2011-02-10T23:45:46Z","timestamp":1297381546000},"page":"623-631","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Studying Life Effects &amp; Effectiveness of Palatopharyngoplasty (SLEEP) Study"],"prefix":"10.1002","volume":"144","author":[{"given":"Edward M.","family":"Weaver","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\/Head &amp; Neck Surgery University of Washington Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. Tucker","family":"Woodson","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\/Head &amp; Neck Surgery Medical College of Wisconsin Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bevan","family":"Yueh","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\/Head &amp; Neck Surgery Medical College of Wisconsin Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\/Head &amp; Neck Surgery Oregon Health &amp; Science University Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael G.","family":"Stewart","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\/Head &amp; Neck Surgery Weill Cornell Medical College New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maureen","family":"Hannley","sequence":"additional","affiliation":[{"name":"Tucson Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristine","family":"Schulz","sequence":"additional","affiliation":[{"name":"American Academy of Otolaryngology\u2013Head &amp; Neck Surgery Foundation Alexandria Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milesh M.","family":"Patel","sequence":"additional","affiliation":[{"name":"American Academy of Otolaryngology\u2013Head &amp; Neck Surgery Foundation Alexandria Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Witsell","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology\/Head &amp; Neck Surgery Duke University Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the SLEEP Study Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,2,10]]},"reference":[{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/19.2.156"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2002.126477"},{"key":"e_1_2_9_4_2","first-page":"27","article-title":"Effects and side\u2010effects of surgery for snoring and obstructive sleep apnea: a systematic review","volume":"32","author":"Franklin KA","year":"2009","journal-title":"Sleep"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2004.11.001"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199506000-00019"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.2105124"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.06.00107805"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2003.12.012"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.02.00306502"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-5998(98)70277-3"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/18.8.659"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.134.8.805"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200311000-00020"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2869.2000.00210.x"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2009.03.022"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2003.09.016"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2003.12.004"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2006.12.029"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2007.08.015"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/22.5.667"},{"key":"e_1_2_9_22_2","first-page":"835","article-title":"An instrument to measure functional status outcomes for disorders of excessive sleepiness","volume":"20","author":"Weaver TE","year":"1997","journal-title":"Sleep"},{"key":"e_1_2_9_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0895-4356(94)90036-1"},{"key":"e_1_2_9_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/14.6.540"},{"key":"e_1_2_9_25_2","doi-asserted-by":"publisher","DOI":"10.1080\/000164800454369"},{"key":"e_1_2_9_26_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-198903001-00015"},{"key":"e_1_2_9_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2004.11.003"},{"key":"e_1_2_9_28_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348940611501102"},{"key":"e_1_2_9_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/27.5.990"},{"key":"e_1_2_9_30_2","doi-asserted-by":"publisher","DOI":"10.1080\/00016480410017954"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0194599810394982","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1177\/0194599810394982","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0194599810394982","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T14:37:22Z","timestamp":1760971042000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1177\/0194599810394982"}},"subtitle":["Subjective Outcomes of Isolated Uvulopalatopharyngoplasty"],"short-title":[],"issued":{"date-parts":[[2011,2,10]]},"references-count":29,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011,4]]}},"alternative-id":["10.1177\/0194599810394982"],"URL":"https:\/\/doi.org\/10.1177\/0194599810394982","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,2,10]]},"assertion":[{"value":"2010-08-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2010-11-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2011-02-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}