{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:05:20Z","timestamp":1787018720340,"version":"build-2736575974"},"reference-count":14,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2011,2,4]],"date-time":"2011-02-04T00:00:00Z","timestamp":1296777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2011,4]]},"abstract":"\n Objective<\/jats:title>\n Regional recurrence is common following surgery for T1\/T2 oral tongue squamous cell carcinoma (SCC). Tumor depth >4.0\u00a0mm is commonly assigned as an indication for prophylactic neck dissection to improve regional control. Prophylactic neck dissection may detect extracapsular extension, a poor prognostic sign where adjuvant chemotherapy is indicated. The hypothesis in this study is that regional recurrence is a significant problem in 2.1\u2010 to 4.0\u2010mm\u2010depth tumors, and detection of extracapsular extension may be important in this group.<\/jats:p>\n <\/jats:sec>\n \n Study Design<\/jats:title>\n Retrospective chart review.<\/jats:p>\n <\/jats:sec>\n \n Setting<\/jats:title>\n Australian tertiary referral center.<\/jats:p>\n <\/jats:sec>\n \n Subjects and Methods<\/jats:title>\n Review of all patients with T1\/T2 oral tongue SCC treated surgically between January 1991 and January 2009 (n = 81).<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Twenty\u2010nine prophylactic and 5 therapeutic neck dissections followed for a median 34\u00a0months (range, 4\u2010132\u00a0months). Tumor depths were 0 to 2.0\u00a0mm (n = 15), 2.1 to 4.0\u00a0mm (n = 18), 4.1 to 7.0\u00a0mm (n = 26), and >7.0\u00a0mm (n = 22). Tumors 2.1 to 4.0\u00a0mm depth had similar rates of occult nodes as 4.1 to 7.0\u00a0mm depth (25% vs 20%). Regional recurrence occurred in 31% overall, 44% in tumors 2.1 to 4.0\u00a0mm, and 27% in tumors 4.1 to 7.0\u00a0mm depth. Prophylactic neck dissection reduced regional recurrence (17% vs 43%,\n P<\/jats:italic>\n =. 02). Patients with pathologically negative necks had lower rates of regional recurrence than those with occult nodes (9% vs 50%,\n P<\/jats:italic>\n <. 01). Extracapsular extension increased regional recurrence (43% vs 7%,\n P<\/jats:italic>\n =. 02), including 25% of dissected necks with tumor depth 2.1 to 4.0\u00a0mm.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Regional recurrence is a significant problem in 2.1\u2010 to 4.0\u2010mm\u2010depth T1\/T2 tongue tumors. Prophylactic neck dissection may improve regional control in patients with adequate primary resection margins and determine need for adjuvant therapies in 2.1\u2010 to 4.0\u2010mm\u2010depth tumors.<\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/0194599810394988","type":"journal-article","created":{"date-parts":[[2011,2,5]],"date-time":"2011-02-05T00:20:15Z","timestamp":1296865215000},"page":"542-548","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Prophylactic Neck Dissection in Early Oral Tongue Squamous Cell Carcinoma 2.1 to 4.0\u00a0mm Depth"],"prefix":"10.1002","volume":"144","author":[{"given":"Matthew J.","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, Head & Neck Surgery Department of Surgery University of Melbourne Royal Melbourne Hospital Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Guiney","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head & Neck Surgery Department of Surgery University of Melbourne Royal Melbourne Hospital Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire E.","family":"Iseli","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head & Neck Surgery Department of Surgery University of Melbourne Royal Melbourne Hospital Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malcolm","family":"Buchanan","sequence":"additional","affiliation":[{"name":"Department of Pathology Royal Melbourne Hospital Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim A.","family":"Iseli","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head & Neck Surgery 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