{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T17:27:29Z","timestamp":1783618049872,"version":"3.55.0"},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2011,3,4]],"date-time":"2011-03-04T00:00:00Z","timestamp":1299196800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2011,6]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>It has been taught that a missing parathyroid adenoma can be within the thyroid. Therefore, thyroid lobectomy is appropriate when an adenoma cannot be found. Unfortunately, this technique is often futile. The purpose of this study is to examine the frequency of unsuccessful thyroid lobectomy in parathyroid surgery and to look at the true incidence and location of intrathyroid parathyroid adenomas (iT\u2010PAs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>A retrospective chart review of 11,163 patients undergoing parathyroid surgery identifying the location of more than 40,000 parathyroid glands.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>A tertiary care center specializing in parathyroid surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>A total of 1163 reoperations for persistent primary hyperparathyroidism (PHPT) were examined for the incidence and outcomes of thyroid lobectomy performed to find iT\u2010PA. A second study examined 10,000 patients undergoing first\u2010time parathyroidectomy to classify the location and incidence of iT\u2010PA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thyroid lobectomy had been previously unsuccessfully performed in 77% cases of PHPT undergoing reoperation. Two or fewer glands were found in 82% prior to lobectomy. The adenoma was subsequently found on the lobectomy side in 64% and on the opposite side in 36%. True iT\u2010PA occurred in only 0.7% of 10,000 primary cases. Another 1.2% were closely adherent to or partially within the thyroid substance. The most common location was the lower lateral quadrant of the thyroid.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The incidence of true iT\u2010PA is less than 1%, occurring in predictable locations. Thyroid lobectomy for a missing parathyroid adenoma is typically unsuccessful and should only rarely, if ever, be performed.<\/jats:p><\/jats:sec>","DOI":"10.1177\/0194599811400366","type":"journal-article","created":{"date-parts":[[2011,3,4]],"date-time":"2011-03-04T23:04:19Z","timestamp":1299279859000},"page":"867-871","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":85,"title":["Intrathyroid Parathyroid Adenoma"],"prefix":"10.1002","volume":"144","author":[{"given":"Arnold","family":"Goodman","sequence":"first","affiliation":[{"name":"Norman Parathyroid Center Wesley Chapel\u2010Tampa Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doug","family":"Politz","sequence":"additional","affiliation":[{"name":"Norman Parathyroid Center Wesley Chapel\u2010Tampa Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose","family":"Lopez","sequence":"additional","affiliation":[{"name":"Norman Parathyroid Center Wesley Chapel\u2010Tampa Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Norman","sequence":"additional","affiliation":[{"name":"Norman Parathyroid Center Wesley Chapel\u2010Tampa Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,3,4]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(05)81188-2"},{"key":"e_1_2_8_3_2","first-page":"814","article-title":"The anatomy of primary hyperparathyroidism","volume":"92","author":"Thompson NW","year":"1992","journal-title":"Surgery"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01655524"},{"key":"e_1_2_8_5_2","first-page":"14","article-title":"Surgical anatomy of human parathyroid glands","volume":"95","author":"Akerstrom G","year":"1984","journal-title":"Surgery"},{"key":"e_1_2_8_6_2","first-page":"195","volume-title":"Medical Embryology","author":"Langman J","year":"1963"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-197603000-00010"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/014107688107400109"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2005.11.009"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(97)00190-6"},{"key":"e_1_2_8_11_2","first-page":"501","article-title":"Hyperparathyroidism and intrathyroid parathyroid gland: 43 cases","volume":"48","author":"Proye C","year":"1994","journal-title":"Ann Chir"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199204000-00002"},{"key":"e_1_2_8_13_2","unstructured":"World Medical Association.Declaration of Helsinki: ethical principles for medical research involving human subjects.http:\/\/www.wma.net\/e\/policy\/pdf\/17c.pdf. Updated September 10 2004."},{"key":"e_1_2_8_14_2","first-page":"147","article-title":"Measuring individual parathyroid gland function in real time during radioguided parathyroidectomy: experience in 8000 operations","volume":"33","author":"Norman J","year":"2008","journal-title":"Minerva Endocrinol"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1055-3207(18)30204-7"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-008-0276-5"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2010.03.040"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2010.03.019"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2006.16.619"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0194599811400366","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1177\/0194599811400366","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0194599811400366","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T11:49:24Z","timestamp":1760960964000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1177\/0194599811400366"}},"subtitle":["Incidence and Location\u2014The Case against Thyroid Lobectomy"],"short-title":[],"issued":{"date-parts":[[2011,3,4]]},"references-count":18,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2011,6]]}},"alternative-id":["10.1177\/0194599811400366"],"URL":"https:\/\/doi.org\/10.1177\/0194599811400366","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,3,4]]},"assertion":[{"value":"2010-09-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2011-01-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2011-03-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}