{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:47:01Z","timestamp":1761007621678,"version":"build-2065373602"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,3,10]],"date-time":"2011-03-10T00:00:00Z","timestamp":1299715200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2011,8]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To analyze outcomes in patients with squamous cell carcinoma (SCCA) of the tonsil from the years 1998 to 2006. To assess factors that may affect disease\u2010specific survival, such as patient characteristics and\/or treatment modality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design and Setting<\/jats:title><jats:p>National Cancer Institute\u2019s Surveillance Epidemiology and End Results (SEER) program.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>The SEER database was used to perform a population\u2010based cohort analysis for patients diagnosed with SCCA of the tonsil from 1998 to 2006. Disease\u2010specific survival was correlated with sex, age, ethnicity, year of diagnosis, and treatment modality in a univariate Cox proportional hazards analysis and a multiple Cox\u2010regression model with and without interaction effect.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Applied inclusion criteria resulted in 8378 patients. Of this patient cohort, 80% were male and 85% were white. The mean patient age at diagnosis was 58.1 years. On univariate and multivariate analyses, ethnicities other than white carried a significantly higher rate of disease\u2010specific death (hazard ratio = 1.71, <jats:italic>P<\/jats:italic> &lt;. 001). Each additional year of age at the time of diagnosis carried approximately a 4% increase in likelihood of disease\u2010specific death. With each passing year of time at diagnosis, patients carried a decreased risk of disease\u2010specific death (<jats:italic>P<\/jats:italic> &lt;. 001); this value was significant in all 3 statistical models. Patients who underwent external\u2010beam radiation had a higher likelihood of disease\u2010specific survival with each passing year at time of diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Population analysis based on the SEER database reveals increased disease\u2010specific survival from tonsillar SCCA in more recent years. This may be because of earlier diagnosis, an increase in less aggressive subtypes of SCCA, and more effective treatment modalities.<\/jats:p><\/jats:sec>","DOI":"10.1177\/0194599811401799","type":"journal-article","created":{"date-parts":[[2011,3,11]],"date-time":"2011-03-11T00:50:46Z","timestamp":1299804646000},"page":"236-241","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Tonsillar Squamous Cell Carcinoma"],"prefix":"10.1002","volume":"145","author":[{"given":"Mia E.","family":"Miller","sequence":"first","affiliation":[{"name":"UCLA Medical Center Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David A.","family":"Elashoff","sequence":"additional","affiliation":[{"name":"UCLA Medical Center Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elliot","family":"Abemayor","sequence":"additional","affiliation":[{"name":"UCLA Medical 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