{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T17:59:19Z","timestamp":1776535159046,"version":"3.51.2"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2011,3,18]],"date-time":"2011-03-18T00:00:00Z","timestamp":1300406400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2011,9]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>This study assesses swallowing function following chemoradiotherapy and neck dissection in head and neck cancer patients and investigates clinical, treatment, and neck dissection factors associated with dysphagia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Case series with chart review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Tertiary care center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>Eighty\u2010eight patients undergoing neck dissection after chemoradiotherapy for advanced head and neck cancer were reviewed. Dysphagia outcome measures included weight loss, diet, gastrostomy tube (GT) dependency, and video swallow findings of aspiration or stenosis. In addition, the researchers created a Diet\/GT Scale, with scores ranging from 1 to 5. Univariate and multivariate analysis of clinical, treatment, or neck dissection factors potentially associated with dysphagia outcome measures was undertaken.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Peak mean weight loss was 17% at 6\u00a0months after chemoradiotherapy. At 12\u00a0months, a soft\/regular diet was taken by 78 of 88 patients (89%), and only 1 of 88 patients (1%) was nil per os. Gastrostomy tube dependence at 6, 12, and 24\u00a0months was 53%, 25%, and 10%, respectively. The Diet\/GT score was 5 (gastrostomy tube removed and soft\/regular diet) for 47% at 6\u00a0months, 74% at 12\u00a0months, and 89% at 24\u00a0months. Multivariate analyses revealed that higher tumor stage was associated with a lower Diet\/GT score at 12\u00a0months (<jats:italic>P<\/jats:italic> =. 02) and gastrostomy dependence at 12\u00a0months (<jats:italic>P<\/jats:italic> =. 01) and 24\u00a0months (<jats:italic>P<\/jats:italic> =. 04).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Despite the addition of neck dissection to chemoradiotherapy, nearly all patients took a soft or regular diet and reached a Diet\/GT score of 5, and only 1% remained nil per os. A higher tumor stage is associated with a lower Diet\/GT score and gastrostomy tube dependency beyond 12\u00a0months.<\/jats:p><\/jats:sec>","DOI":"10.1177\/0194599811403075","type":"journal-article","created":{"date-parts":[[2011,3,19]],"date-time":"2011-03-19T20:25:23Z","timestamp":1300566323000},"page":"428-434","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Swallowing Function following Postchemoradiotherapy Neck Dissection"],"prefix":"10.1002","volume":"145","author":[{"given":"Claudia I.","family":"Chapuy","sequence":"first","affiliation":[{"name":"Department of Medical Oncology Dana\u2010Farber Cancer Institute Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald J.","family":"Annino","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology Department of Surgery Brigham and Women\u2019s Hospital Boston Massachusetts 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