{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T11:05:42Z","timestamp":1778583942749,"version":"3.51.4"},"reference-count":5,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,3,31]],"date-time":"2011-03-31T00:00:00Z","timestamp":1301529600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2011,8]]},"abstract":"<jats:p>Chronic rhinosinusitis with nasal polyps (CRSwNP) is connected to a chronic inflammatory process with the activation of different immune components. Eotaxin\u20103, acidic mammalian chitinase (AMCase), and interleukin (IL)\u201313 as focal immune factors have been detected in CRSwNP, but their importance and relationship are still being investigated. This study aims to detect the expression of AMCase, IL\u201013, and eotaxin\u20103\u00a0in the mRNA level and investigate their roles and relationships in CRSwNP. Twenty\u2010four subjects with eosinophilic CRSwNP and 11 controls were included in the study. Tissues were obtained by endoscopic sinus surgery. Target genes were detected by real\u2010time reverse transcription\u2013polymerase chain reaction. AMCase, eotaxin\u20103, and IL\u201013 were detected in all CRSwNP and controls. The expression of AMCase, eotaxin\u20103, IL\u201013, and mRNA was significantly higher in patients with CRSwNP than in the control group. There was a significantly positive correlation not only between AMCase and eotaxin\u20103 but also between IL\u201013 and eotaxin\u20103\u00a0in CRSwNP. Increased AMCase, IL\u201013, and eotaxin\u20103\u00a0might lead to the Th2\u00a0inflammatory cascade reaction.<\/jats:p>","DOI":"10.1177\/0194599811403077","type":"journal-article","created":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T00:13:42Z","timestamp":1301616822000},"page":"324-326","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Role of Eotaxin\u20103\u00a0in Chronic Rhinosinusitis with Nasal Polyps"],"prefix":"10.1002","volume":"145","author":[{"given":"ZhaoWei","family":"Gu","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology China Medical University affiliated Shengjing Hospital Shenyang City Liaoning Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MingZhu","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology China Medical University affiliated Shengjing Hospital Shenyang City Liaoning Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ZhiWei","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology China Medical University affiliated Shengjing Hospital Shenyang City Liaoning Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,3,31]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2006.11.011"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1095336"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.2500\/ajr.2006.20.2869"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2009.06.013"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2007.10.024"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0194599811403077","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1177\/0194599811403077","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0194599811403077","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T14:27:17Z","timestamp":1760970437000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1177\/0194599811403077"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,3,31]]},"references-count":5,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,8]]}},"alternative-id":["10.1177\/0194599811403077"],"URL":"https:\/\/doi.org\/10.1177\/0194599811403077","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,3,31]]},"assertion":[{"value":"2010-12-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2011-02-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2011-03-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}