{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:39:23Z","timestamp":1761007163015,"version":"build-2065373602"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2011,7,12]],"date-time":"2011-07-12T00:00:00Z","timestamp":1310428800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2011,9]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate whether BRAF mutation of papillary thyroid carcinoma (PTC) has different predictive values for regional lymph node (LN) metastasis according to tumor size.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Prospective cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>A tertiary hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>From January 2009 to August 2009, the authors prospectively enrolled 102 consecutive patients with unifocal PTC based on the findings of ultrasonography\u2010guided fine\u2010needle aspiration biopsy (FNAB). BRAF mutation was tested on preoperative FNAB specimens. Total thyroidectomy and bilateral central neck dissection (\u00b1 lateral neck dissection) was performed for all patients. Among 102 patients, 71 who were confirmed to have unifocal PTC by the surgical pathology were finally selected. The 71 patients were classified into 3\u00a0groups according to their tumor size: group I, \u22640.5\u00a0cm; group II, &gt;0.5\u00a0cm and \u22641\u00a0cm; and group III, &gt;1\u00a0cm. LN metastasis was evaluated in the surgical specimen as a dependent variable. The authors investigated whether BRAF mutation is predictive of LN metastasis in each group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, BRAF mutation was a significant predictor of LN metastasis (<jats:italic>P<\/jats:italic> =. 045). When patients were classified into 3\u00a0groups, frequency of LN metastasis increased with tumor size: 4.8%, 50.0%, and 66.7% (<jats:italic>P<\/jats:italic> &lt;. 001). However, the frequency of BRAF mutation was not different among 3\u00a0groups: 61.9%, 56.3%, and 72.2% (<jats:italic>P<\/jats:italic> =. 536). BRAF mutation was predictive of LN metastasis only in group II (<jats:italic>P<\/jats:italic> =. 026).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>BRAF mutation of PTC may have differential predictive values for LN metastasis, according to tumor size.<\/jats:p><\/jats:sec>","DOI":"10.1177\/0194599811404649","type":"journal-article","created":{"date-parts":[[2011,7,13]],"date-time":"2011-07-13T20:19:52Z","timestamp":1310588392000},"page":"422-427","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Preoperative BRAF Mutation Has Different Predictive Values for Lymph Node Metastasis according to Tumor Size"],"prefix":"10.1002","volume":"145","author":[{"given":"Yoon Kyoung","family":"So","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery Inje University College of Medicine Haeundae Paik Hospital Pusan South 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