{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T11:23:04Z","timestamp":1761823384325,"version":"build-2065373602"},"reference-count":8,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2011,5,3]],"date-time":"2011-05-03T00:00:00Z","timestamp":1304380800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2011,9]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess graft uptake rates with the use of cyanoacrylate adhesives in myringoplasty procedures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Case series with chart review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Tertiary care center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>Five hundred forty\u2010two patients selected with safe central perforations were divided into 4\u00a0groups based on perforation size and each divided into 2 subgroups depending on the presence or absence of preexisting pathology on the remnant tympanic membrane. Myringoplasty without ossicular reconstruction was done postaurally or by transcanal approach, with inlay graft placed and adhesive applied. Ear pack was removed on the seventh postoperative day. Graft uptake rates, graft uptake time (neotympanum intact and mobile), and postoperative sequelae were noted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Graft uptake was about 99% at 3\u00a0months postsurgery. Residual perforation was seen in 2 patients in group 2 and 1\u00a0in group 4 and thinned\u2010out tympanum in 1 patient in group 4. Mean uptake time was 21\u00a0days. Neotympanum mobility was sluggish in 9 cases postoperatively in group 4 and in 2 cases in group 3. Patients with successful (neotympanum intact and mobile) graft uptake showed significant improvement. Postoperative inflammatory signs in the external auditory canal were seen in 3 cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Cyanoacrylate use in myringoplasty obtains graft uptake rates of 99% compared with most studies, which report 80% to 90%. This also allows removal of the pack by the seventh day, allowing close follow\u2010up of the graft and less patient discomfort. Importantly, it has not interfered with the formation of the neotympanum or compromised hearing improvement.<\/jats:p><\/jats:sec>","DOI":"10.1177\/0194599811404963","type":"journal-article","created":{"date-parts":[[2011,5,3]],"date-time":"2011-05-03T20:46:35Z","timestamp":1304455595000},"page":"442-445","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Graft Uptake Rates with Isoamyl\u20102\u2010Cyanoacrylate in Myringoplasty Procedures"],"prefix":"10.1002","volume":"145","author":[{"given":"Dasari Samuel","family":"Deenadayal","sequence":"first","affiliation":[{"name":"Department of Otolaryngology and Head &amp; Neck Surgery Yashoda Hospital Secunderabad India"},{"name":"Aarti Clinic Secunderabad India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ajay Kumar","family":"Neeli","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology and Head &amp; Neck Surgery Yashoda Hospital Secunderabad India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saif Hameed","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology and Head &amp; Neck Surgery Yashoda Hospital Secunderabad India"},{"name":"Resurrection Health Care Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,5,3]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02974319"},{"issue":"4","key":"e_1_2_8_3_2","first-page":"284","article-title":"Intra\u2010operative findings influence in myringoplasty anatomical result","volume":"10","author":"Bunzen D","year":"2006","journal-title":"Arq Int Otorrinolaringol"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215106005561"},{"issue":"3","key":"e_1_2_8_5_2","first-page":"529","article-title":"Results of myringoplasty and type I tympanoplasty with the use of fascia, cartilage and perichondrium grafts [in Polish]","volume":"58","author":"Gierek T","year":"2004","journal-title":"Klinika Laryngologii Otolaryngol Pol"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02990582"},{"issue":"2","key":"e_1_2_8_7_2","first-page":"91","article-title":"Does indermil glue improve success rates in myringoplasty? Interim analysis of a prospective trial","volume":"121","author":"England RJ","year":"2000","journal-title":"Rev Laryngol Otol Rhinol (Bord)"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100088149"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.3109\/00016488209130902"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0194599811404963","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1177\/0194599811404963","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0194599811404963","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T11:53:48Z","timestamp":1760961228000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1177\/0194599811404963"}},"subtitle":["A 10\u2010Year Retrospective Study"],"short-title":[],"issued":{"date-parts":[[2011,5,3]]},"references-count":8,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,9]]}},"alternative-id":["10.1177\/0194599811404963"],"URL":"https:\/\/doi.org\/10.1177\/0194599811404963","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"type":"print","value":"0194-5998"},{"type":"electronic","value":"1097-6817"}],"subject":[],"published":{"date-parts":[[2011,5,3]]},"assertion":[{"value":"2010-07-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2011-03-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2011-05-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}