{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T22:16:13Z","timestamp":1770502573892,"version":"3.49.0"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2011,6,2]],"date-time":"2011-06-02T00:00:00Z","timestamp":1306972800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2011,9]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Recent findings support the crucial role of microcirculatory disturbance and ischemia for hearing impairment especially after noise\u2010induced hearing loss (NIHL). The aim of this study was to establish an animal model for in vivo analysis of cochlear microcirculation and hearing function after a loud noise to allow precise measurements of both parameters in vivo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Randomized controlled trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Animal study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>After assessment of normacusis (0\u00a0minutes) using evoked auditory brainstem responses (ABRs), noise (106\u2010dB sound pressure level [SPL]) was applied to both ears in 6 guinea pigs for 30\u00a0minutes while unexposed animals served as controls. In vivo fluorescence microscopy of the stria vascularis capillaries was performed after surgical exposure of 1 cochlea. ABR measurements were derived from the contralateral ear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After noise exposure, red blood cell velocity was reduced significantly by 24.3% (120\u00a0minutes) and further decreased to 44.5% at the end of the observation (210\u00a0minutes) in contrast to stable control measurements. Vessel diameters were not affected in both groups. A gradual decrease of segmental blood flow became significant (38.1%) after 150\u00a0minutes compared with controls. Hearing thresholds shifted significantly from 20.0 \u00b1 5.5\u00a0dB SPL (0\u00a0minutes) to 32.5 \u00b1 4.2\u00a0dB SPL (60\u00a0minutes) only in animals exposed to loud noise.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>With regard to novel treatments targeting the stria vascularis in NIHL, this standardized model allows us to analyze in detail cochlear microcirculation and hearing function in vivo.<\/jats:p><\/jats:sec>","DOI":"10.1177\/0194599811407829","type":"journal-article","created":{"date-parts":[[2011,6,3]],"date-time":"2011-06-03T08:47:54Z","timestamp":1307090874000},"page":"463-469","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Modeling the Measurements of Cochlear Microcirculation and Hearing Function after Loud Noise"],"prefix":"10.1002","volume":"145","author":[{"given":"Warangkana","family":"Arpornchayanon","sequence":"first","affiliation":[{"name":"Walter Brendel Center for Experimental Medicine (WBex) University of Munich (LMU) Munich Germany"},{"name":"Department of Pharmacology Faculty of Medicine Chiang Mai University Chiang Mai Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Canis","sequence":"additional","affiliation":[{"name":"IFB<sup>LMU<\/sup> \u2010 Integrated Center for Research and Treatment of Vertigo Balance and Ocular Motor Disorders University of Munich (LMU) Munich Germany"},{"name":"Department of Otorhinolaryngology University of Goettingen Goettingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Suckfuell","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology University of Munich (LMU) Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fritz","family":"Ihler","sequence":"additional","affiliation":[{"name":"Walter Brendel Center for Experimental Medicine (WBex) University of Munich (LMU) Munich Germany"},{"name":"IFB<sup>LMU<\/sup> \u2010 Integrated Center for Research and Treatment of Vertigo Balance and Ocular Motor Disorders University of Munich (LMU) Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernhard","family":"Olzowy","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology University of Munich (LMU) Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian","family":"Strieth","sequence":"additional","affiliation":[{"name":"Walter Brendel Center for Experimental Medicine (WBex) University of Munich (LMU) Munich Germany"},{"name":"Department of Otorhinolaryngology J. W. Goethe\u2010University Frankfurt\/Main Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,6,2]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1080\/000164801300366598"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5955(87)90021-9"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.3109\/00016489009125158"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00186226"},{"key":"e_1_2_8_6_2","first-page":"322","article-title":"Cochlear vascular changes in response to loud noise","volume":"16","author":"Quirk WS","year":"1995","journal-title":"Am J Otol"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1159\/000259195"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1999.tb08644.x"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1159\/000046807"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1954.00710050743005"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5955(89)90147-0"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348945506400420"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-009-1036-2"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.593327"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5955(87)90013-X"},{"key":"e_1_2_8_16_2","first-page":"293","article-title":"Computer assisted leukocyte adhesion measurement in intravital microscopy","volume":"8","author":"Zeintl H","year":"1989","journal-title":"Int J Microcirc Clin Exp"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1515\/bmte.1997.42.6.168"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0026-2862(74)90043-0"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5955(87)90012-8"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.3109\/00016486209126927"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.3109\/00016489209100783"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02114761"},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.1159\/000013846"},{"key":"e_1_2_8_24_2","first-page":"17","article-title":"Sound\u2010induced cochlear ischemia\/hypoxia as a mechanism of hearing loss","volume":"2","author":"Nuttall AL","year":"1999","journal-title":"Noise Health"},{"key":"e_1_2_8_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2006.10.006"},{"key":"e_1_2_8_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(00)02733-5"},{"key":"e_1_2_8_27_2","doi-asserted-by":"publisher","DOI":"10.3109\/00016488809102853"},{"key":"e_1_2_8_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2006.01.011"},{"key":"e_1_2_8_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.20764"},{"key":"e_1_2_8_30_2","doi-asserted-by":"publisher","DOI":"10.1159\/000063736"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0194599811407829","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1177\/0194599811407829","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0194599811407829","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T11:53:43Z","timestamp":1760961223000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1177\/0194599811407829"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,6,2]]},"references-count":29,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,9]]}},"alternative-id":["10.1177\/0194599811407829"],"URL":"https:\/\/doi.org\/10.1177\/0194599811407829","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,6,2]]},"assertion":[{"value":"2011-02-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2011-03-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2011-06-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}