{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T10:37:24Z","timestamp":1788691044523,"version":"build-2803163510"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2011,5,13]],"date-time":"2011-05-13T00:00:00Z","timestamp":1305244800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2011,10]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine whether intratympanic (IT) dexamethasone ameliorates cisplatin\u2010induced ototoxicity in a mouse model of presbycusis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Controlled experimental study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Translational science experimental laboratory.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>Auditory brainstem response (ABR) thresholds of 24\u2010month\u2010old CBA\/J\u2010NIA mice treated with cisplatin were compared 7\u00a0days after daily IT injections of dexamethasone (24\u00a0mg\/mL) or saline.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Because of high (100%) mortality at 16\u00a0mg\/kg, a single cisplatin dose of 14\u00a0mg\/kg intraperitoneally was used. At this latter dose, pre\u2010IT and post\u2010IT treatment ABR thresholds were available in 13 of 16\u00a0mice. In IT saline\u2013treated ears, cisplatin produced up to 9.5\u2010dB ABR threshold elevations. In IT dexamethasone\u2013treated ears, little protection against cisplatin was observed at 8 or 16\u00a0kHz where mean ABR thresholds were elevated. At 24 and 32\u00a0kHz, mean ABR threshold elevations were minimal at 0.6 to 1.4\u00a0dB. This protection was statistically significant (<jats:italic>P<\/jats:italic> \u2264. 02).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These results demonstrate, for the first time, a protective effect of a treatment against an ototoxic agent in the presence of age\u2010related hearing loss. In the presence of age\u2010related hearing loss, the protective effect of IT dexamethasone has a frequency gradient, being greatest in the high\u2010frequency region of the cochlea. This latter finding contrasts with our previous report in young mice, in which the protective effect of IT dexamethasone was in the low\u2010frequency region of the cochlea.<\/jats:p><\/jats:sec>","DOI":"10.1177\/0194599811409304","type":"journal-article","created":{"date-parts":[[2011,5,13]],"date-time":"2011-05-13T23:55:08Z","timestamp":1305330908000},"page":"635-640","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Can Intratympanic Dexamethasone Protect against Cisplatin Ototoxicity in Mice with Age\u2010Related Hearing Loss?"],"prefix":"10.1002","volume":"145","author":[{"given":"Kourosh","family":"Parham","sequence":"first","affiliation":[{"name":"Department of Surgery Division of Otolaryngology\u2013Head &amp; Neck Surgery University of Connecticut Health Center Farmington Connecticut 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