{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:05:20Z","timestamp":1787018720368,"version":"build-2736575974"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2011,6,9]],"date-time":"2011-06-09T00:00:00Z","timestamp":1307577600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2011,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The results of sentinel lymph node biopsy (SLNB) can be useful for staging and deciding on adjuvant treatment for patients with head and neck melanoma. False\u2010negative SLNB can result in treatment delay. This study aimed to evaluate the characteristics and outcome of patients with false\u2010negative SLNB in cutaneous melanoma of the head and neck.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>Longitudinal cohort study using a prospective institutional tumor registry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Academic health center.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Subjects and Methods<\/jats:title>\n                    <jats:p>Data from 153 patients who underwent SLNB for melanoma of the head and neck were analyzed. False\u2010negative biopsy was defined as recurrence of tumor in a previously identified negative nodal basin. Statistical analysis was performed on registry data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Positive sentinel lymph nodes were identified in 19 (12.4%) patients. False\u2010negative SLNB was noted in 9 (5.9%) patients, with a false\u2010negative SLNB rate of 32.1%. Using multivariate regression analysis, only examination of a single sentinel lymph node was a significant predictor of false\u2010negative SLNB (\n                      <jats:italic>P<\/jats:italic>\n                      =. 01). The mean treatment delay for the false\u2010negative SLNB group was 470\u00a0days compared with 23\u00a0days in the positive SLNB group (\n                      <jats:italic>P<\/jats:italic>\n                      &lt;. 001). The 2\u2010year overall survival of patients with false\u2010negative SLNB was 75% compared with 84% and 98% in positive and negative SLNB groups, respectively (\n                      <jats:italic>P<\/jats:italic>\n                      =. 02).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>False\u2010negative SLNB is more likely to occur when a single sentinel lymph node is harvested. There is significant treatment delay in patients with false\u2010negative SLNB. False\u2010negative SLNB is associated with poor outcome in patients with melanoma of the head and neck.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0194599811411878","type":"journal-article","created":{"date-parts":[[2011,6,10]],"date-time":"2011-06-10T04:55:18Z","timestamp":1307681718000},"page":"606-611","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["False\u2010Negative Sentinel Lymph Node Biopsy in Head and Neck Melanoma"],"prefix":"10.1002","volume":"145","author":[{"given":"Matthew W.","family":"Miller","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Oregon Health and Science University Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John T.","family":"Vetto","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology Oregon Health and Science University Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus M.","family":"Monroe","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Oregon Health and Science University Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roshanthi","family":"Weerasinghe","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology Oregon Health and Science University Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter E.","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Oregon Health and Science University Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil D.","family":"Gross","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Oregon Health and Science University Portland Oregon 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