{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:46:15Z","timestamp":1761007575417,"version":"build-2065373602"},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2011,8,8]],"date-time":"2011-08-08T00:00:00Z","timestamp":1312761600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To examine whether there is an association of eotaxin\u20101 gene polymorphisms with nasal polyposis (NP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Cross\u2010sectional study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Tertiary referral center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>The study group included 85 patients with NP and 93 controls without sinonasal disease. Genotypes of eotaxin\u20101 (\u2212384 A&gt;G and +67 G&gt;A) were identified by restriction fragment length polymorphism analyses after polymerase chain reaction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The \u2212384 A&gt;G and +67 G&gt;A single nucleotide polymorphisms were higher in patients with NP than in controls (<jats:italic>P<\/jats:italic> =. 044 and <jats:italic>P<\/jats:italic> =. 019, respectively). However, their relation was statistically poor (association coefficient = 0.18). Consistent with this result, comparisons of allele frequencies for both single nucleotide polymorphisms were not significantly different (\u2212384 A&gt;G, <jats:italic>P<\/jats:italic> =. 164; +67 G&gt;A, <jats:italic>P<\/jats:italic> =. 144).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this study, eotaxin\u20101 \u2212384 A&gt;G or 67 G&gt;A genotypes were not associated with susceptibility to NP.<\/jats:p><\/jats:sec>","DOI":"10.1177\/0194599811417359","type":"journal-article","created":{"date-parts":[[2011,8,9]],"date-time":"2011-08-09T02:13:54Z","timestamp":1312856034000},"page":"1036-1039","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Lack of Association between Eotaxin\u20101 Gene Polymorphisms and Nasal Polyposis"],"prefix":"10.1002","volume":"145","author":[{"given":"Suna","family":"Ekinci","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Baskent University Faculty of Medicine Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Selim S.","family":"Erbek","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Baskent University Faculty of Medicine Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erkan","family":"Yurtcu","sequence":"additional","affiliation":[{"name":"Department of Medical Biology Baskent University Faculty of Medicine Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feride I.","family":"Sahin","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics Baskent University Faculty of Medicine Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,8,8]]},"reference":[{"key":"e_1_2_7_2_2","first-page":"1","article-title":"European position paper on rhinosinusitis and nasal polyps","volume":"20","author":"European Academy 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