{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:42:31Z","timestamp":1761007351696,"version":"build-2065373602"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,9,7]],"date-time":"2011-09-07T00:00:00Z","timestamp":1315353600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>No specific epidemiology data are available for carcinoma of the uvula. This study aims to analyze the epidemiological characteristics and treatment outcomes of carcinoma of the uvula at the authors\u2019 institution.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Case series with chart review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Service of ENT\u2013Head and Neck Surgery, University Hospital Complex of Santiago de Compostela (CHUS), Spain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>Retrospective epidemiological study of 21\u00a0male patients, mean age 57.52 years, diagnosed with squamous cell carcinoma of the uvula in the CHUS between January 1990 and June 2009.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Most patients presented with odynophagia and exophytic lesions microscopically consistent with moderately differentiated squamous cell carcinoma. Despite the size of the lesions (T1 and T2), more than half of the patients had lymph node metastases at diagnosis. More than 90.0% of patients with lesions larger than 1\u00a0cm presented with lymph node metastases. Although more than 70.0% of patients underwent a neck dissection in the first year after diagnosis, only 25.0% were free of metastatic disease. Recurrences occurred at a mean of 14\u00a0months from baseline in more than 50.0% of cases. Of the patients, 52.4% died, with a median survival of 38.15\u00a0months after diagnosis. The overall 5\u2010year survival was 39.0%. According to tumor size, 5\u2010year survival was 53.0% for T1 and 27.0% for T2.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>According to the data, clinical features of carcinoma of the uvula correspond with aggressive tumors, with rapid onset and a major negative impact regardless of tumor size at diagnosis. Early stage patients benefit significantly from surgical treatments with neck dissections.<\/jats:p><\/jats:sec>","DOI":"10.1177\/0194599811421110","type":"journal-article","created":{"date-parts":[[2011,9,8]],"date-time":"2011-09-08T01:45:36Z","timestamp":1315446336000},"page":"81-87","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["T1\u2010T2 Squamous Cell Carcinoma of the Uvula"],"prefix":"10.1002","volume":"146","author":[{"given":"Federico","family":"Espinosa Restrepo","sequence":"first","affiliation":[{"name":"Service of ENT\u2013Head and Neck Surgery University Hospital Complex of Santiago de Compostela (CHUS) Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel","family":"Mart\u00ednez Capoccioni","sequence":"additional","affiliation":[{"name":"Service of ENT\u2013Head and Neck Surgery University Hospital Complex of Santiago de Compostela (CHUS) Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Mart\u00edn Mart\u00edn","sequence":"additional","affiliation":[{"name":"Service of ENT\u2013Head and Neck Surgery University Hospital Complex of Santiago de Compostela (CHUS) Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,9,7]]},"reference":[{"volume-title":"Head and Neck Surgery and Oncology","year":"2003","author":"Shah JP","key":"e_1_2_8_2_2"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000175075.69706.64"},{"key":"e_1_2_8_4_2","first-page":"76","article-title":"Oral cavity risk factors: experts\u2019 opinions and literature support","volume":"39","author":"Stucken E","year":"2010","journal-title":"J Otolaryngol Head Neck Surg"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-010-9564-z"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0b013e32832984c0"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-88441-7"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/lary.20141"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.3322\/canjclin.45.6.328"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/019459988809900103"},{"key":"e_1_2_8_11_2","first-page":"6","volume-title":"Anatomy of the Pharynx: Medical Surgical Encyclopedia of Otorhinolaryngology and Head and Neck Surgery","author":"Dehesdin D","year":"2000"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00238-010-0417-5"},{"volume-title":"Anatomy, Physiology, Pathology of the Lymphatic Vessels","year":"1874","author":"Sappey PC","key":"e_1_2_8_13_2"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20126"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/lary.20053"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1186\/1758-3284-2-9"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00178098"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdq306"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2009.09.074"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-1-4160-5202-9.50014-4"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2005.05.008"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.2880140204"},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-198106000-00012"},{"key":"e_1_2_8_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2008.12.015"},{"key":"e_1_2_8_25_2","first-page":"165","article-title":"Carcinoma of the oropharynx: soft palate","volume":"13","author":"Garret PG","year":"1984","journal-title":"J Otolaryngol"},{"key":"e_1_2_8_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2010.00905.x"},{"key":"e_1_2_8_27_2","first-page":"278","article-title":"Survival time and prognostic factors of oral cancer in Ubon Ratchathani Cancer Center","volume":"93","author":"Kruaysawat W","year":"2010","journal-title":"J Med Assoc Thai"},{"key":"e_1_2_8_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-8140(87)80229-3"},{"key":"e_1_2_8_29_2","first-page":"306","article-title":"Carcinoma of the soft palate and uvula: an analysis of the results and the reasons for failures. 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