{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T11:05:05Z","timestamp":1791889505082,"version":"4.3.4"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2011,11,10]],"date-time":"2011-11-10T00:00:00Z","timestamp":1320883200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2012,3]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>(1) Evaluate audiometric protocols and recommend protocols with best sensitivity and specificity for magnetic resonance imaging (MRI) screening of acoustic tumors; (2) determine clinical risks (false negative) of missing acoustic tumors and potential wastes in screening (false positive) nonacoustic tumors or radiologically \u201cnormal\u201d cases; and (3) identify the decibel difference and range of frequencies compared by the best\u2010performing protocols.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Cross\u2010sectional study with chart review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Ear, nose, and throat (ENT); audiology; and radiology departments in a tertiary\u2010care hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>Three\u2010year cohort (2006\u20102009) of 1751 ENT patients underwent MRI screening and pure\u2010tone audiometry indicating sensorineural hearing loss. Audiometric protocols were ranked by highest sensitivity to acoustic tumors, specificity A to nonacoustic tumors, and specificity B to \u201cradiologically normal\u201d cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No audiometric protocols achieved 100% sensitivity or specificity rates. Only 2 protocols achieved \u226590% sensitivity: the AMCLASS\u2010A\u2010Urben protocol (93.16%) and the Mangham protocol (91.58%). Eleven of 15 protocols for specificity A and 12 of 15 protocols for specificity B achieved \u226550%. Clinical risks ranged from 6.84% to 18.95%, whereas potential wastes ranged from 33.56% to 68.37% for specificity A and 31.76% to 66.86% for specificity B. Interaural difference parameters indicating highest mean sensitivity were on the order of \u226510\u00a0dB, \u226515\u00a0dB, and \u226520\u00a0dB. For frequency comparison parameters, \u201c2 or more adjacent frequency\u201d and \u201csingle\u2010frequency\u201d comparison indicated higher mean sensitivity than the \u201caveraged multifrequency\u201d comparison. Mean specificity showed an opposite pattern.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>For optimum sensitivity, the Mangham protocol is preferred (sensitivity, 91.58%; specificity A, 44.23%; specificity B, 44.91%), which proposes a \u226510\u2010dB interaural difference, averaging 1 to 8\u00a0kHz. For optimum specificity, the American Academy of Otolaryngology\u2013Head and Neck Surgery protocol is preferred (sensitivity, 87.37%; specificity A, 65.38%; specificity B, 66.04%), which proposes \u226515\u00a0dB between ears, averaging 0.5 to 3\u00a0kHz.<\/jats:p><\/jats:sec>","DOI":"10.1177\/0194599811427384","type":"journal-article","created":{"date-parts":[[2011,11,11]],"date-time":"2011-11-11T01:32:19Z","timestamp":1320975139000},"page":"438-447","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Three\u2010Year Ear, Nose, and Throat Cross\u2010sectional Analysis of Audiometric Protocols for Magnetic Resonance Imaging Screening of Acoustic Tumors"],"prefix":"10.1002","volume":"146","author":[{"given":"Teddy Caramoan","family":"Cheng","sequence":"first","affiliation":[{"name":"Barts and the London NHS Trust London England"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Wareing","sequence":"additional","affiliation":[{"name":"Barts and the London NHS Trust London England"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,11,10]]},"reference":[{"key":"e_1_2_9_2_2","unstructured":"ShohetJA.Skull base tumors and other CPA tumors. eMedicine.February 2009.http:\/\/emedicine.medscape.com\/article\/883090\u2010overview. 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