{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T09:46:18Z","timestamp":1768643178860,"version":"3.49.0"},"reference-count":41,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2011,11,18]],"date-time":"2011-11-18T00:00:00Z","timestamp":1321574400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2012,3]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the efficacy and safety of low\u2010dose intratympanic gentamicin (ITG) compared with intratympanic dexamethasone (ITD) in patients with intractable unilateral M\u00e9ni\u00e8re disease (MD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Open prospective randomized controlled study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Tertiary referral center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>Sixty patients affected by definite unilateral MD were enrolled between January 1, 2007, and June 30, 2008. Thirty\u2010two patients were treated with a buffered gentamicin solution injected in the middle ear (maximum of 2\u00a0injections); 28 patients were treated with ITD (4\u00a0mg\/mL, 3\u00a0injections at intervals of 1 every 3\u00a0days). Mean outcome measurements consisted of control of vertigo attacks, pure tone average (PTA), speech discrimination score, functional disability score, and statistical analysis using repeated measures analysis of variance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the ITG group at 2\u2010year follow\u2010up, complete control of vertigo (class A) was achieved in 26 patients (81%) and substantial control of vertigo (class B) in 4 patients (12.5%). In the ITD group, class A was achieved in 12 (43%), and class B in 5 (18%) patients. In the gentamicin group, 4 patients showed a reduction in PTA of \u226510\u00a0dB. In the ITD group, PTA was unchanged or slightly improved in 16 patients (belonging to class A\u2010B) and worse in 12.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Low\u2010dose ITG achieved better outcome than ITD in the control of vertigo attacks in patients suffering from unilateral MD, with a very low incidence of hearing deterioration. ITD offers poorer vertigo control rate, and hearing preservation is achieved only in cases with no vertigo recurrences.<\/jats:p><\/jats:sec>","DOI":"10.1177\/0194599811429432","type":"journal-article","created":{"date-parts":[[2011,11,18]],"date-time":"2011-11-18T22:50:34Z","timestamp":1321656634000},"page":"430-437","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":103,"title":["Intratympanic Treatment of Intractable Unilateral M\u00e9ni\u00e8re Disease"],"prefix":"10.1002","volume":"146","author":[{"given":"Augusto Pietro","family":"Casani","sequence":"first","affiliation":[{"name":"Department of Neurosciences Otorhinolaryngology Unit Pisa University Hospital Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Piaggi","sequence":"additional","affiliation":[{"name":"Department of Energy and Systems Engineering University of Pisa Pisa 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