{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:18:35Z","timestamp":1791217115499,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2011,12,13]],"date-time":"2011-12-13T00:00:00Z","timestamp":1323734400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Basic fibroblast growth factor (bFGF) promotes the regeneration of denervated nerves. The aim of this study was to evaluate the regeneration\u2010facilitating effects of novel facial nerve decompression surgery using bFGF in a gelatin hydrogel in patients with severe Bell palsy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Prospective clinical study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Tertiary referral center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>Twenty patients with Bell palsy after more than 2 weeks following the onset of severe paralysis were treated with the new procedure. The facial nerve was decompressed between tympanic and mastoid segments via the mastoid. A bFGF\u2010impregnated biodegradable gelatin hydrogel was placed around the exposed nerve. Regeneration of the facial nerve was evaluated by the House\u2010Brackmann (H\u2010B) grading system. The outcomes were compared with the authors\u2019 previous study, which reported outcomes of the patients who underwent conventional decompression surgery (n = 58) or conservative treatment (n = 43).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The complete recovery (H\u2010B grade 1) rate of the novel surgery (75.0%) was significantly better than the rate of conventional surgery (44.8%) and conservative treatment (23.3%). Every patient in the novel decompression surgery group improved to H\u2010B grade 2 or better even when undergone between 31 and 99\u00a0days after onset.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Advantages of this decompression surgery are low risk of complications and long effective period after onset of the paralysis. To the authors\u2019 knowledge, this is the first clinical report of the efficacy of bFGF using a new drug delivery system in patients with severe Bell palsy.<\/jats:p><\/jats:sec>","DOI":"10.1177\/0194599811431661","type":"journal-article","created":{"date-parts":[[2011,12,13]],"date-time":"2011-12-13T20:49:23Z","timestamp":1323809363000},"page":"641-646","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Facial Nerve Decompression Surgery Using bFGF\u2010Impregnated Biodegradable Gelatin Hydrogel in Patients with Bell Palsy"],"prefix":"10.1002","volume":"146","author":[{"given":"Naohito","family":"Hato","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Ehime University School of Medicine Ehime Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jumpei","family":"Nota","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Ehime University School of 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