{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T13:36:47Z","timestamp":1782481007818,"version":"3.54.5"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,1,11]],"date-time":"2012-01-11T00:00:00Z","timestamp":1326240000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the short\u2010term outcomes of using cross\u2010linked porcine collagen for vocal fold augmentation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Case series with planned data collection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Tertiary referral hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>Twenty consecutive patients of unilateral vocal fold paralysis (UVFP) were recruited, including 10\u00a0males and 10 females. All the subjects received videolaryngostroboscopic (VLS) evaluation for the glottic closure pattern, perceptual grading using the GRB scale (grade, roughness, breathiness), acoustic analysis, maximal phonation time (MPT), and Voice Handicap Index (VHI) questionnaire. Purified telopeptide\u2010free, glutaraldehyde cross\u2010linked porcine collagen was injected under local anesthesia with fiberscopic guidance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Treatment outcomes were evaluated 3\u00a0months after the injection. Fifteen (75%) of 20 patients reported complete resolution of symptoms, whereas the other 5 (25%) patients had substantial improvements. The median score of perceptual analysis of voice quality showed significant improvements from G2\/R2\/B2 to G1\/R1\/B0 (<jats:italic>P<\/jats:italic> &lt;. 001). Glottic closure pattern under stroboscopy had improved from \u201cpredominantly open\u201d before the procedure to a \u201chalf\u2010open and half\u2010close\u201d pattern after the procedure (<jats:italic>P<\/jats:italic> &lt;. 001). Acoustic analysis demonstrated significant improvements of jitter and normalized noise energy (<jats:italic>P<\/jats:italic> &lt;. 05). Maximal phonation time revealed a significant improvement from 7.5 \u00b1 3.2\u00a0seconds to 13.1 \u00b1 3.9\u00a0seconds (<jats:italic>P<\/jats:italic> &lt;. 01). The VHI had also decreased from 53 \u00b1 25 points to 27 \u00b1 20 points (<jats:italic>P<\/jats:italic> &lt;. 01). No patients had serious adverse events during the follow\u2010up period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This case series demonstrated that porcine collagen may be a suitable material for temporary vocal fold augmentation.<\/jats:p><\/jats:sec>","DOI":"10.1177\/0194599811434003","type":"journal-article","created":{"date-parts":[[2012,1,12]],"date-time":"2012-01-12T01:23:24Z","timestamp":1326331404000},"page":"606-610","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Preliminary Report of Vocal Fold Augmentation with Cross\u2010Linked Porcine Collagen"],"prefix":"10.1002","volume":"146","author":[{"given":"Chi\u2010Te","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Far Eastern Memorial Hospital Taipei Taiwan"},{"name":"Oriental Institute of Technology Taipei 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