{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T13:41:20Z","timestamp":1790084480656,"version":"4.0.1"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,1,27]],"date-time":"2012-01-27T00:00:00Z","timestamp":1327622400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Nasal polyposis is a disease known to be associated with asthma. The long\u2010term effects of surgical treatment on lower airways have not been sufficiently studied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>One\u2010year follow\u2010up of a double\u2010blind, randomized, placebo\u2010controlled study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>The study was conducted at the Karolinska University Hospital, Stockholm, Sweden.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>Fifty\u2010one patients, age 18 years or older, with nasal polyposis and asthma were evaluated 1 year after endoscopic sinus surgery (ESS). Outcomes included dyspnea\/cough scores, mean daily peak expiratory flow rate, spirometry, butanol test, olfaction scores, peak nasal inspiratory flow, polyp scores, and health\u2010related quality of life (SF\u201036).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The short\u2010term postsurgery improvements in asthma symptom scores, daily peak expiratory flow rate, all nasal parameters including olfaction, and quality\u2010of\u2010life scores were generally maintained 1 year after ESS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Endoscopic sinus surgery had beneficial long\u2010term effects on asthma, olfaction, and quality of life in patients with nasal polyposis. This is the first study to show long\u2010term benefits of ESS on butanol tests in patients with nasal polyposis.<\/jats:p><\/jats:sec>","DOI":"10.1177\/0194599811435638","type":"journal-article","created":{"date-parts":[[2012,1,28]],"date-time":"2012-01-28T03:43:35Z","timestamp":1327722215000},"page":"834-841","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["One Year after Endoscopic Sinus Surgery in Polyposis"],"prefix":"10.1002","volume":"146","author":[{"given":"Anders","family":"Ehnhage","sequence":"first","affiliation":[{"name":"Department of Clinical Science Intervention and Technology Division of Otorhinolaryngology Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petter","family":"Olsson","sequence":"additional","affiliation":[{"name":"Department of Clinical Science Intervention and Technology Division of Otorhinolaryngology Karolinska Institutet 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