{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:38:14Z","timestamp":1761007094543,"version":"build-2065373602"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,2,2]],"date-time":"2012-02-02T00:00:00Z","timestamp":1328140800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Mannose\u2010binding lectin is an important component of innate immunity; it initiates the lectin pathway of complement activation critical for innate immunity. Failure of local innate defenses may result in defective responses that lead to the persistent carriage of microorganisms or ongoing inflammation. This study investigated the role of mannose\u2010binding lectin levels and the frequency of the 6 functional mannose\u2010binding lectin polymorphisms in Turkish individuals with nasal polyposis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>A case\u2010control study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>University hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>Fifty\u2010one patients with nasal polyposis and 53 healthy controls were enrolled. Serum mannose\u2010binding lectin levels were obtained by enzyme\u2010linked immunosorbent assay (ELISA) using the mannose\u2010binding lectin oligomer ELISA kit. Mannose\u2010binding lectin 2 genotyping was performed by isolating the genomic DNA from leukocytes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean mannose\u2010binding lectin levels were 1693.2 and 1887.8\u00a0in the patient and control group, respectively. Although mannose\u2010binding lectin levels were lower in the patient group, the difference was not statistically significant (<jats:italic>P<\/jats:italic> &gt;. 05). No overall association was observed between the mannose\u2010binding lectin genotype and susceptibility to nasal polyposis (95% confidence interval = 0.716\u20134.389, odds ratio = 1.773). The mutant allele frequencies of the 3 structural polymorphisms did not differ significantly between the nasal polyposis patients and the controls (<jats:italic>P<\/jats:italic> =. 659).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Mannose\u2010binding lectins are not involved in the pathogenesis of nasal polyposis in adult Turkish patients, but additional research is needed for further comment.<\/jats:p><\/jats:sec>","DOI":"10.1177\/0194599812436945","type":"journal-article","created":{"date-parts":[[2012,2,3]],"date-time":"2012-02-03T20:31:12Z","timestamp":1328301072000},"page":"79-84","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Does Mannose\u2010Binding Lectin Have a Role in Adult Turkish Patients with Nasal Polyposis?"],"prefix":"10.1002","volume":"147","author":[{"given":"Erdem","family":"Eren","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Head &amp; Neck Surgery Atat\u00fcrk Research and Training Hospital Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ra\u015fit","family":"Midilli","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head &amp; Neck Surgery Faculty of Medicine Ege University \u0130zmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emin","family":"Karaca","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics Faculty of Medicine Ege University \u0130zmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00fcseyin","family":"Onay","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics Faculty of Medicine Ege University \u0130zmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B\u00fclent","family":"Karc\u0131","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head &amp; Neck Surgery Faculty of Medicine Ege University \u0130zmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cihangir","family":"\u00d6zk\u0131nay","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics Faculty of Medicine Ege University \u0130zmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,2,2]]},"reference":[{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.112374"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004050050210"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2006.03.034"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-5890(03)00155-X"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2007.05.004"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.155.6.3013"},{"key":"e_1_2_9_8_2","doi-asserted-by":"crossref","first-page":"3169","DOI":"10.4049\/jimmunol.161.6.3169","article-title":"Different molecular events result in low protein level of mannan\u2010binding lectin in population from southeast Africa and South America","volume":"161","author":"Madsen HO","year":"1998","journal-title":"J Immunol"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-009-0030-5"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.2500\/ajr.2008.22.3127"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2008.02.001"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20071164"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200008033430506"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2004.07.013"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.8.4430"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2007.08.003"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2006.06.005"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2006.03007.x"},{"key":"e_1_2_9_19_2","first-page":"1","article-title":"European Position Paper on Rhinosinusitis and Nasal Polyps group","volume":"20","author":"Fokkens W","year":"2007","journal-title":"Rhinol Suppl"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2005.02881.x"},{"key":"e_1_2_9_21_2","first-page":"187","article-title":"Increased serum complement component 3 and mannose\u2010binding lectin levels in adult Chinese patients with chronic rhinosinusitis","volume":"47","author":"Cui YH","year":"2009","journal-title":"Rhinology"},{"key":"e_1_2_9_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.2006.00649.x"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0194599812436945","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1177\/0194599812436945","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0194599812436945","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T11:48:30Z","timestamp":1760960910000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1177\/0194599812436945"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2,2]]},"references-count":21,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["10.1177\/0194599812436945"],"URL":"https:\/\/doi.org\/10.1177\/0194599812436945","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"type":"print","value":"0194-5998"},{"type":"electronic","value":"1097-6817"}],"subject":[],"published":{"date-parts":[[2012,2,2]]},"assertion":[{"value":"2011-08-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-01-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-02-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}