{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T19:58:05Z","timestamp":1773431885181,"version":"3.50.1"},"reference-count":8,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,2,27]],"date-time":"2012-02-27T00:00:00Z","timestamp":1330300800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Nodal metastasis from oral tongue squamous cell carcinoma follows a predictable pattern. Isolated level IV involvement, termed <jats:italic>skip metastases<\/jats:italic>, is described. This study attempts to identify the incidence of skip metastasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Case series with chart review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Tertiary academic hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects<\/jats:title><jats:p>Fifty\u2010two consecutive patients with T1 to T4\u00a0N0 stage who underwent excision of the primary tumor with neck dissection (levels I\u2010IV).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective study. The incidence of isolated level III or IV involvement pathologically and isolated nodal recurrence in levels III and IV was analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Pathologically, isolated level III involvement occurred in 2 (3.8%) patients. Isolated level IV occurred in 1 (1.9%) patient. Mean follow\u2010up was 24\u00a0months. Two patients had recurrence in the primary site; 1 had recurrence in neck level II. None had recurrence in level III or IV.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Skip metastasis is rare in T1 and T2 oral tongue squamous cell carcinoma. Inclusion of level IV is not mandatory in selective neck dissection for clinically and radiologically negative neck disease in early tumors (T1 and T2).<\/jats:p><\/jats:sec>","DOI":"10.1177\/0194599812439664","type":"journal-article","created":{"date-parts":[[2012,2,28]],"date-time":"2012-02-28T00:09:50Z","timestamp":1330387790000},"page":"275-277","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Isolated Skip Nodal Metastasis Is Rare in T1 and T2 Oral Tongue Squamous Cell Carcinoma"],"prefix":"10.1002","volume":"147","author":[{"given":"Deepak","family":"Balasubramanian","sequence":"first","affiliation":[{"name":"Department of Head and Neck Surgery and Oncology Amrita Institute of medical Sciences Kochi Kerala India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krishnakumar","family":"Thankappan","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery and Oncology Amrita Institute of medical Sciences Kochi Kerala India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azhar Jan","family":"Battoo","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery and Oncology Amrita Institute of medical Sciences Kochi Kerala India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayuri","family":"Rajapurkar","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery and Oncology Amrita Institute of medical Sciences Kochi Kerala India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moni Abraham","family":"Kuriakose","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery Mazumdar Shaw Cancer Centre Narayana Hrudayalaya Bangalore India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Subramania","family":"Iyer","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery and Oncology Amrita Institute of medical Sciences Kochi Kerala India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,2,27]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1368-8375(03)00010-1"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(05)80554-9"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02303619"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1993.01880210046007"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.2880110203"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2008.06.001"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0347(199701)19:1<14::AID-HED3>3.0.CO;2-Y"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2005.09.025"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0194599812439664","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1177\/0194599812439664","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0194599812439664","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:36:38Z","timestamp":1760956598000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1177\/0194599812439664"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2,27]]},"references-count":8,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,8]]}},"alternative-id":["10.1177\/0194599812439664"],"URL":"https:\/\/doi.org\/10.1177\/0194599812439664","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,2,27]]},"assertion":[{"value":"2012-01-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-01-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-02-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}