{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T02:21:27Z","timestamp":1781835687179,"version":"3.54.5"},"reference-count":48,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,4,24]],"date-time":"2012-04-24T00:00:00Z","timestamp":1335225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To report the long\u2010term significance of sentinel lymph node (SLN) biopsy on prognosis, determine false\u2010negative SLN occurrences, and determine risk factors for death and recurrence in a large series of patients with head and neck melanoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Case series with tumor registry review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Academic tertiary care medical center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>A database review was performed of all patients who underwent SLN biopsy for head and neck melanoma from 1994 to 2009. End points assessed were SLN status, recurrence, false\u2010negative SLN results, and survival comparing SLN\u2010positive and SLN\u2010negative patients and different locations. Survival curves and multivariate analyses were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>SLN biopsy was performed in 365 patients. SLNs were identified in 98.6% of patients with a mean of 3.7\u00a0nodes removed from 1.6\u00a0nodal basins per patient. Median follow\u2010up was 8 years. The SLN was positive in 40 (11%) patients. SLN\u2013positive patients had significantly thicker melanomas, higher recurrence (<jats:italic>P<\/jats:italic> &lt;. 0001), and a significant decrease in overall survival compared with SLN\u2010negative patients (<jats:italic>P<\/jats:italic> &lt;. 002). Scalp melanoma patients had significantly thicker melanomas and an elevated risk of SLN positivity, recurrence, and death compared with other sites. Seventeen of 365 SLN\u2010negative patients developed regional nodal disease for a false\u2010omission rate of 5.2% and a negative predictive value of a negative SLN to be 94.8%. Risks for false negative\u2010SLN occurrences included thick melanomas and scalp melanomas.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>SLN biopsy is accurate in head and neck melanoma and provides significant prognostic data. Scalp melanoma patients present with thicker tumors with an increase in SLN positivity and false\u2010negative SLN occurrences.<\/jats:p><\/jats:sec>","DOI":"10.1177\/0194599812444268","type":"journal-article","created":{"date-parts":[[2012,4,25]],"date-time":"2012-04-25T20:45:39Z","timestamp":1335386739000},"page":"699-706","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Long\u2010Term Prognosis and Significance of the Sentinel Lymph Node in Head and Neck Melanoma"],"prefix":"10.1002","volume":"147","author":[{"given":"Brian M.","family":"Parrett","sequence":"first","affiliation":[{"name":"The Buncke Clinic Division of Plastic Surgery California Pacific Medical Center San Francisco California USA"},{"name":"University of California\u2013San Francisco San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Kashani\u2010Sabet","sequence":"additional","affiliation":[{"name":"Center for Melanoma Research &amp; Treatment California Pacific Medical Center San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark I.","family":"Singer","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery California Pacific Medical Center San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Li","sequence":"additional","affiliation":[{"name":"University of Southern California Los Angeles California USA"},{"name":"Novartis Molecular Diagnostics Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suresh","family":"Thummala","sequence":"additional","affiliation":[{"name":"Center for Melanoma Research &amp; Treatment California Pacific Medical Center San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niloofar","family":"Fadaki","sequence":"additional","affiliation":[{"name":"Center for Melanoma Research &amp; Treatment California Pacific Medical Center San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanley P. 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