{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T05:01:29Z","timestamp":1771045289673,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,4,20]],"date-time":"2012-04-20T00:00:00Z","timestamp":1334880000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the effect of adenotonsillectomy (T&amp;A) in obese children with obstructive sleep apnea (OSA) and to compare changes in high\u2010sensitivity C\u2010reactive protein (hs\u2010CRP) levels before and 6\u00a0months after T&amp;A in obese children with OSA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Before and after study with planned data collection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Tertiary care, university\u2010based pediatric hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>Seventy\u2010five obese children with OSA were included. Clinical information such as the apnea\u2010hypopnea index (AHI), nadir oxyhemoglobin saturation (SaO<jats:sub>2<\/jats:sub>), and body mass index (BMI) were recorded. The hs\u2010CRP level was determined before T&amp;A and at the 6\u2010month follow\u2010up examination.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Reductions in AHI (21.96 \u00b1 9.277 before T&amp;A vs 8.64 \u00b1 5.997 after 6\u00a0months of T&amp;A) and higher levels of nadir SaO<jats:sub>2<\/jats:sub> (74.08 \u00b1 7.860 before T&amp;A vs 86.87 \u00b1 5.586 after 6\u00a0months of T&amp;A) were observed. The hs\u2010CRP levels were obviously correlated with BMI (<jats:italic>r<\/jats:italic> = 0.7948, <jats:italic>P<\/jats:italic> &lt;. 001). Other than AHI (<jats:italic>r<\/jats:italic> = 0.0579, <jats:italic>P<\/jats:italic> =. 6217) in obese children, however, hs\u2010CRP levels showed no changes 6\u00a0months after T&amp;A therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>T&amp;A treatment improves clinical signs and symptoms in obese children but does not reduce chronic inflammation as reflected by hs\u2010CRP. To lower the risks of cardiovascular disease and diabetes mellitus morbidity, other treatments should be taken into account.<\/jats:p><\/jats:sec>","DOI":"10.1177\/0194599812444419","type":"journal-article","created":{"date-parts":[[2012,4,21]],"date-time":"2012-04-21T02:22:19Z","timestamp":1334974939000},"page":"538-543","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Impact of Adenotonsillectomy on High\u2010Sensitivity C\u2010Reactive Protein Levels in Obese Children with Obstructive Sleep Apnea"],"prefix":"10.1002","volume":"147","author":[{"given":"Lijuan","family":"Chu","sequence":"first","affiliation":[{"name":"Chongqing Medical University Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongbing","family":"Yao","sequence":"additional","affiliation":[{"name":"Otorhinolaryngological Department of Children\u2019s Hospital of Chongqing Medical University Chongqing 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