{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T18:34:54Z","timestamp":1775500494614,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,4,11]],"date-time":"2012-04-11T00:00:00Z","timestamp":1334102400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To establish the efficacy of proton pump inhibitors (PPI) in the treatment of adenoid hypertrophy in children.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Randomized controlled double\u2010blinded clinical trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Population<\/jats:title>\n                    <jats:p>Forty children, aged 2 to 12 years, with adenoid hypertrophy fulfilling the inclusion and exclusion criteria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients were randomly allocated into 2\u00a0groups: one to be treated with oral Losec MUPS for a period of 2\u00a0months (treatment group) and the other to be given a low\u2010dose vitamin C tablet for the same period (control group). The patients were reviewed on 2 occasions during the 2\u2010month study period, during which endoscopy was performed to examine the adenoid glands to assess their size and the larynx to assess signs of reflux disease. Examination of tonsillar size was also performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>There was a significant reduction in adenoid size in the treatment group, but the control group also demonstrated a significant reduction in adenoid size. Comparison between the 2\u00a0groups in terms of adenoid grade change between the first and second visits did not reveal any significant statistical difference.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The results of this study do not demonstrate any efficacy of PPIs for adenoid hypertrophy in children, and these drugs should not be used for this purpose.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0194599812444528","type":"journal-article","created":{"date-parts":[[2012,4,12]],"date-time":"2012-04-12T01:59:08Z","timestamp":1334195948000},"page":"329-334","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The Role of Proton Pump Inhibitors in Adenoid Hypertrophy in Children"],"prefix":"10.1002","volume":"147","author":[{"given":"Farim Rizal Wong","family":"Iqbal","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology Faculty of Medicine National University of Malaysia Bandar Tun Razak Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bee See","family":"Goh","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Faculty of Medicine National University of Malaysia Bandar Tun Razak Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ami","family":"Mazita","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Faculty of Medicine National University of Malaysia Bandar Tun Razak Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,4,11]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-5876(82)90001-5"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200211000-00004"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200112000-00018"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.793231"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2003.07.018"},{"key":"e_1_2_8_7_2","first-page":"1","volume-title":"Scott\u2010Brown\u2019s Otolaryngology Pediatric Otolaryngology","author":"Cowen DL"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-5998(99)70408-0"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.126.7.831"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2005.02.019"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.moo.0000193177.62074.fd"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2005.02.021"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2007.11.003"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2009.08.022"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348941011900808"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-4486.2008.01852.x"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1808-8694(15)31279-9"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0194599812444528","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1177\/0194599812444528","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0194599812444528","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:36:45Z","timestamp":1760956605000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1177\/0194599812444528"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4,11]]},"references-count":16,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,8]]}},"alternative-id":["10.1177\/0194599812444528"],"URL":"https:\/\/doi.org\/10.1177\/0194599812444528","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.717953758.793459366","asserted-by":"object"}]},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,4,11]]},"assertion":[{"value":"2011-11-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-03-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-04-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}