{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T11:02:18Z","timestamp":1762340538762,"version":"build-2065373602"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,5,11]],"date-time":"2012-05-11T00:00:00Z","timestamp":1336694400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Genetic variation of <jats:italic>cadheri23<\/jats:italic> (<jats:italic>cdh23<\/jats:italic>; 753G&gt;A in exon 7) has been implicated with age\u2010related hearing impairment (ARHI) in mice. This study aimed to test the association of the <jats:italic>CDH23<\/jats:italic> tag single nucleotide polymorphism (SNP) in intron 7 with ARHI in Han Chinese.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Individual cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Tertiary medical center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>A total of 1175 Han Chinese subjects were divided into the case group (n = 310, 26% with poorest hearing) and the control group (n = 308, the 26% with best hearing) according to the Z<jats:sub>high<\/jats:sub> score converted from the original frequency\u2010specific hearing thresholds. The <jats:italic>CDH23<\/jats:italic> SNP locus (rs7087735: C\/T) in intron 7 (coordinate: 72996763) shown in the HapMap was genotyped with correlation to the hearing phenotype.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The genotype distributions of <jats:italic>CDH23<\/jats:italic> (CC\/CT\/TT) were not significantly different between the case and control group (<jats:italic>P<\/jats:italic> =. 489). Compared with genotype CC, the odds ratios of the genotypes CT and TT for ARHI were not significantly different after adjustment for other environmental factors (<jats:italic>P<\/jats:italic> =. 299 for CT; <jats:italic>P<\/jats:italic> =. 610 for TT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Despite that the <jats:italic>Ahl<\/jats:italic> allele of <jats:italic>Cdh23<\/jats:italic> had been implicated with ARHI in mice, we found no positive association of the <jats:italic>CDH23<\/jats:italic> tag SNP in intron 7 with ARHI in Han Chinese.<\/jats:p><\/jats:sec>","DOI":"10.1177\/0194599812446904","type":"journal-article","created":{"date-parts":[[2012,5,12]],"date-time":"2012-05-12T01:22:29Z","timestamp":1336785749000},"page":"531-534","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Association of <i>Cadherin23<\/i> Single Nucleotide Polymorphism with Age\u2010Related Hearing Impairment in Han Chinese"],"prefix":"10.1002","volume":"147","author":[{"given":"Juen\u2010Haur","family":"Hwang","sequence":"first","affiliation":[{"name":"Graduate Institute of Clinical Medicine College of Medicine National Taiwan University Taipei Taiwan"},{"name":"Department of Otolaryngology Buddhist Dalin Tzu\u2010Chi General Hospital Chiayi Taiwan"},{"name":"School of Medicine Tzu Chi University Hualien Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kris Sun","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Biology Harvard College Harvard University Cambridge Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chien\u2010Chi","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology National Taiwan University Hospital Taipei Taiwan"},{"name":"Department of Medical Genetics National Taiwan University Hospital Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tien\u2010Chen","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology National Taiwan University Hospital Taipei 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Van LaerL HuentelmanMJ et al.GRM7 variants confer susceptibility to age\u2010related hearing impairment.Hum Mol Genet.2009;18:785\u2010796.","DOI":"10.1093\/hmg\/ddn402"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.133.9.929"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/lary.21771"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1226"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrg796"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.AUD.0000120362.69077.0B"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1119(01)00761-2"}],"container-title":["Otolaryngology\u2013Head and Neck 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