{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:38:42Z","timestamp":1761007122649,"version":"build-2065373602"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,6,19]],"date-time":"2012-06-19T00:00:00Z","timestamp":1340064000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The Unified Airways Hypothesis suggests an involvement of the upper airways in asthma. We aimed to evaluate the association between subjective sino\u2010nasal complaints, nasal air flow, and sino\u2010nasal quality of life (QOL) in patients with asthma compared with nonasthmatic subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Case\u2010control study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>A tertiary referral center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>Symptoms, quality of life, and nasal airflow were assessed in 91 asthmatics and 95\u00a0nonasthmatic controls with Visual Analog Scale (VAS, 0\u2010100), Sino\u2010Nasal Outcome Test (SNOT\u201020), and Peak Nasal Inspiratory Flow (PNIF), respectively. Asthma and allergy status were assessed by Asthma Control Questionnaire (ACQ) and skin prick test or specific IgE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Asthmatic patients (men\/women, 37\/54; mean age, 43.7 years; range, 19\u201064 years) reported significantly more nasal obstruction (mean VAS, 37\u00a0mm; SD = 26, 95% CI, 32\u201043 vs 9\u00a0mm, SD = 11, 95% CI, 7\u201011, <jats:italic>P<\/jats:italic> &lt;. 001) and lower sino\u2010nasal quality of life (mean SNOT\u201020, 1.3; SD = 0.8, 95% CI, 1.1\u20101.5 vs 0.4, SD = 0.5, 95% CI, 0.3\u20100.5, <jats:italic>P<\/jats:italic> &lt;. 001) than controls (men\/women, 42\/53; mean age, 43.8 years; range, 20\u201065 years). PNIF was significantly lower in asthmatic patients than controls (mean PNIF, 84 l\/min; SD = 24, 95% CI, 79\u201089 vs 100 l\/min SD = 24, 95% CI, 95\u2010105, <jats:italic>P<\/jats:italic> &lt;. 001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Both allergic and nonallergic asthma were associated with increased sino\u2010nasal symptoms, reduced sino\u2010nasal QOL, and reduced inspiratory nasal air flow compared to controls. This provides further evidence of the clinical importance of the upper airway in the diagnostic and therapeutic management of asthma patients beyond the scope of allergy.<\/jats:p><\/jats:sec>","DOI":"10.1177\/0194599812451408","type":"journal-article","created":{"date-parts":[[2012,6,21]],"date-time":"2012-06-21T09:07:37Z","timestamp":1340269657000},"page":"950-957","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Sino\u2010Nasal Characteristics in Asthmatic Patients"],"prefix":"10.1002","volume":"147","author":[{"given":"Wenche Moe","family":"Thorstensen","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery St Olavs Hospital University Hospital of Trondheim Norway"},{"name":"Institute of Neuroscience Norwegian University of Science and Technology Trondheim Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vegard","family":"Bugten","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery St Olavs Hospital University Hospital of Trondheim Norway"},{"name":"Institute of Neuroscience Norwegian University of Science and Technology Trondheim Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malcolm","family":"Sue\u2010Chu","sequence":"additional","affiliation":[{"name":"Department of Thoracic Medicine St Olavs Hospital University Hospital of Trondheim Norway"},{"name":"Institute of Circulation and Imaging Norwegian University of Science and Technology Trondheim Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nils Petter Wold","family":"Fossland","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery St Olavs Hospital University Hospital of Trondheim Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P\u00e5l Richard","family":"Romundstad","sequence":"additional","affiliation":[{"name":"Institute of Public Health and General Practice Norwegian University of Science and Technology Trondheim Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sverre Karmhus","family":"Steinsv\u00e5g","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery Sorlandet Hospital Kristiansand Norway"},{"name":"Department of Otolaryngology, Head and Neck Surgery, Kristiansand Haukeland University Hospital Bergen Norway"},{"name":"University of Bergen Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,6,19]]},"reference":[{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2007.02.023"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2007.01620.x"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.4045\/tidsskr.08.0394"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2003.00105.x"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00063198-199901000-00006"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.09.013"},{"key":"e_1_2_10_8_2","first-page":"104","article-title":"Allergic rhinitis and asthma in the athlete","volume":"27","author":"Randolph CC","year":"2006","journal-title":"Allergy Asthma Proc"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2007.11.002"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2007.01545.x"},{"issue":"4","key":"e_1_2_10_11_2","first-page":"iv1","volume":"63","author":"British Guideline on the Management of Asthma","year":"2008","journal-title":"Thorax"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2002.121022"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2007.01.024"},{"key":"e_1_2_10_14_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3003.1999.14d29.x"},{"key":"e_1_2_10_15_2","first-page":"659","article-title":"Reference spirometric values using techniques and equipment that meet ATS recommendations","volume":"123","author":"Crapo RO","year":"1981","journal-title":"Am Rev Respir Dis"},{"key":"e_1_2_10_16_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00034805"},{"key":"e_1_2_10_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e318173a025"},{"key":"e_1_2_10_18_2","doi-asserted-by":"publisher","DOI":"10.1001\/archoto.2009.50"},{"key":"e_1_2_10_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2003.09.047"},{"key":"e_1_2_10_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2273.2004.00885.x"},{"key":"e_1_2_10_21_2","doi-asserted-by":"publisher","DOI":"10.1080\/000164800750000388"},{"key":"e_1_2_10_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2010.11.004"},{"key":"e_1_2_10_23_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.09-3066"},{"key":"e_1_2_10_24_2","first-page":"32","article-title":"Peak nasal inspiratory flow; normal range in adult population","volume":"44","author":"Ottaviano G","year":"2006","journal-title":"Rhinology"},{"key":"e_1_2_10_25_2","first-page":"200","article-title":"Does peak nasal inspiratory flow relate to peak expiratory flow?","volume":"46","author":"Ottaviano G","year":"2008","journal-title":"Rhinology"},{"key":"e_1_2_10_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2008.01729.x"},{"key":"e_1_2_10_27_2","doi-asserted-by":"publisher","DOI":"10.2500\/ajr.2008.22.3172"},{"key":"e_1_2_10_28_2","doi-asserted-by":"publisher","DOI":"10.1177\/194589240501900404"},{"key":"e_1_2_10_29_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2009.02011.x"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0194599812451408","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1177\/0194599812451408","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0194599812451408","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T11:35:23Z","timestamp":1760960123000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1177\/0194599812451408"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6,19]]},"references-count":28,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,11]]}},"alternative-id":["10.1177\/0194599812451408"],"URL":"https:\/\/doi.org\/10.1177\/0194599812451408","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"type":"print","value":"0194-5998"},{"type":"electronic","value":"1097-6817"}],"subject":[],"published":{"date-parts":[[2012,6,19]]},"assertion":[{"value":"2012-01-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-05-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-06-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}