{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T17:33:31Z","timestamp":1772645611574,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,11,6]],"date-time":"2012-11-06T00:00:00Z","timestamp":1352160000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Acute otitis externa (AOE) is a common but preventable ear condition. Clinical guidelines issued in 2006 recommended topical treatments for uncomplicated AOE, but systemic antimicrobials appear to be commonly prescribed. The objective of this analysis was to describe pre\u2010 and postguideline prescribing patterns by clinician specialty and antimicrobial type and assess trends over time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Retrospective longitudinal analysis of a large insurance database.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Outpatient departments in the United States.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Initial outpatient visits in 2004 to 2010 for AOE (excluding visits with complicating conditions) were extracted from an insurance database. Prescription drug claims were linked and categorized by clinician specialty and antimicrobial type.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The analysis included 907,261\u00a0initial outpatient visits. Use of systemic antimicrobials declined by 4.9% (95% confidence interval [CI], 4.1%, 5.7%) from 36.5% of initial visits in 2004 to 32.1% in 2010. Use of systemic antimicrobials varied by specialty. Systemic antimicrobials were prescribed in 47.1% of 2010 emergency department (ED) visits (\u22126.9% from 2004, 95% CI \u221212.3, \u22121.5), 25.9% of otolaryngologist visits (\u22121.6%, 95% CI \u22125.6, 2.4), and 20.4% of pediatrician visits (\u22126.6%, 95% CI \u22128.8, \u22124.4). Penicillins were prescribed most frequently (42.3% of systemic prescriptions in 2010), followed by cephalosporins (19.8%), erythromycin\/macrolides (17.4%), and quinolones (11.1%). Opioids were prescribed in 26.4% of ED visits and 9% of outpatient visits.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Use of systemic antimicrobials declined over time, but one\u2010third of 2010 visits resulted in systemic antimicrobials, despite exclusion of visits with complicating factors. Use of systemic antimicrobials varied by specialty. Further educational efforts and outreach to other specialties might be warranted.<\/jats:p><\/jats:sec>","DOI":"10.1177\/0194599812467000","type":"journal-article","created":{"date-parts":[[2012,11,6]],"date-time":"2012-11-06T23:29:47Z","timestamp":1352244587000},"page":"128-134","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Antimicrobial and Analgesic Prescribing Patterns for Acute Otitis Externa, 2004\u20102010"],"prefix":"10.1002","volume":"148","author":[{"given":"Sarah A.","family":"Collier","sequence":"first","affiliation":[{"name":"Waterborne Disease Prevention Branch National Center for Enteric and Zoonotic Infectious Diseases Centers for Disease Control and Prevention Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele C.","family":"Hlavsa","sequence":"additional","affiliation":[{"name":"Waterborne Disease Prevention Branch National Center for Enteric and Zoonotic Infectious Diseases Centers for Disease Control and Prevention Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily W.","family":"Piercefield","sequence":"additional","affiliation":[{"name":"Waterborne Disease Prevention Branch National Center for Enteric and Zoonotic Infectious Diseases Centers for Disease Control and Prevention Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J.","family":"Beach","sequence":"additional","affiliation":[{"name":"Waterborne Disease Prevention Branch National Center for Enteric and Zoonotic Infectious Diseases Centers for Disease Control and Prevention Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,11,6]]},"reference":[{"key":"e_1_2_8_2_2","first-page":"927","article-title":"Otitis externa: a practical guide to treatment and prevention","volume":"63","author":"Sander R","year":"2001","journal-title":"Am Fam Physician"},{"key":"e_1_2_8_3_2","first-page":"CD004740","article-title":"Interventions for acute otitis externa","volume":"1","author":"Kaushik V","year":"2010","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_4_2","first-page":"605","article-title":"Estimated burden of acute otitis externa\u2014United States, 2003\u20102007","volume":"60","author":"Centers for Disease Control and Prevention","year":"2011","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2006.02.014"},{"key":"e_1_2_8_6_2","first-page":"510","article-title":"Otitis externa","author":"Hajioff D","year":"2010","journal-title":"Clin Evid (Online)"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200207000-00005"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.inf.0000109958.65053.4e"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.3122\/15572625-12-1-1"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/0194599811406797"},{"key":"e_1_2_8_11_2","volume-title":"Prevention Quality Indicators Technical Specifications","author":"Agency for Healthcare and Research Quality","year":"2011"},{"key":"e_1_2_8_12_2","unstructured":"SAS Institute.Usage Note 37344: how can I estimate rate differences using a poisson model and get a confidence interval?(October 2009).http:\/\/support.sas.com\/kb\/37\/344.html. 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