{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T09:26:14Z","timestamp":1768555574700,"version":"3.49.0"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,1,11]],"date-time":"2013-01-11T00:00:00Z","timestamp":1357862400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The objective of this study was to systematically review patient\u2010reported outcomes of long\u2010term macrolide therapy, compared with any other treatment, for adults with chronic rhinosinusitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Sources<\/jats:title><jats:p>EMBASE and PubMed databases were searched in October 2011.<\/jats:p><\/jats:sec><jats:sec><jats:title>Review Methods<\/jats:title><jats:p>A total of 1216 citations were screened initially by a single author, 23 full\u2010text manuscripts were evaluated by 2 authors using structured data abstraction forms to assess for inclusion criteria and study quality, and 3 studies were included in the final review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>This review finds that 3 prospective clinical studies have evaluated the effect of macrolide therapy for chronic rhinosinusitis. Based on the limited data, there is limited scientific evidence to support the use of long\u2010term macrolide therapy for chronic rhinosinusitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Further clinical research is needed to determine whether there may be a subgroup effect based on the underlying inflammatory disease process.<\/jats:p><\/jats:sec>","DOI":"10.1177\/0194599812470427","type":"journal-article","created":{"date-parts":[[2013,1,12]],"date-time":"2013-01-12T01:44:55Z","timestamp":1357955095000},"page":"366-373","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Macrolide Therapy for Chronic Rhinosinusitis"],"prefix":"10.1002","volume":"148","author":[{"given":"Melissa A.","family":"Pynnonen","sequence":"first","affiliation":[{"name":"Department of Otolaryngology University of Michigan Health System Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giri","family":"Venkatraman","sequence":"additional","affiliation":[{"name":"Section of Otolaryngology Dartmouth\u2010Hitchcock Medical Center Lebanon New Hampshire USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Greg E.","family":"Davis","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology University of Washington Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,1,11]]},"reference":[{"issue":"249","key":"e_1_2_9_2_2","first-page":"1","article-title":"Summary health statistics for U.S. adults: National Health Interview Survey, 2009","author":"Pleis JR","year":"2010","journal-title":"Vital Health Stat 10"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2007.07.021"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2005.08.002"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2009.07.006"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.2174\/1381612043383304"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2535"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2007.06.726"},{"issue":"20","key":"e_1_2_9_9_2","first-page":"1","article-title":"European position paper on rhinosinusitis and nasal polyps 2007","author":"Fokkens W","year":"2007","journal-title":"Rhinol Suppl"},{"issue":"5","key":"e_1_2_9_10_2","first-page":"CD008233","article-title":"Systemic antibiotics for chronic rhinosinusitis without nasal polyps in adults","author":"Piromchai P","year":"2011","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_9_11_2","unstructured":"Review Manager (RevMan) [Computer program]. 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