{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T12:47:26Z","timestamp":1771073246808,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,1,11]],"date-time":"2013-01-11T00:00:00Z","timestamp":1357862400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To compare the efficacy of intratympanic injections of methylprednisolone (ITMP) and intratympanic injections of gentamicin (ITG) to control the symptoms of M\u00e9ni\u00e8re's disease and to evaluate their effect on hearing level.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>A historical cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Tertiary referral center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>Eighty\u2010nine patients affected by M\u00e9ni\u00e8re's disease were included in this study, of whom 47 were treated with ITG and 42 were treated with ITMP. Two periods of follow\u2010up were considered: 0 to 6\u00a0months and 6 to 12\u00a0months after the intratympanic injections (ITI). Mean outcome measurements consisted of control of vertigo attacks, tinnitus, and aural fullness; pure\u2010tone average (PTA); and speech discrimination score (SDS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The 2\u00a0groups had the same number of vertigo spells per month before ITI (<jats:italic>P<\/jats:italic> =. 883). Six to 12\u00a0months after ITI, 82.9% of the ITG group and 48.1% of the ITMP group achieved complete control of vertigo (<jats:italic>P<\/jats:italic> =. 004). There was better control of tinnitus and aural fullness with ITG than with ITMP (<jats:italic>P<\/jats:italic> \u2264. 002). The 2\u00a0groups had a statistically significant difference in hearing level before ITI (<jats:italic>P<\/jats:italic> \u2264. 001). This difference was no longer present 6 to 12\u00a0months after ITI (<jats:italic>P<\/jats:italic> &gt;. 05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Intratympanic injections of gentamicin are more efficient than ITMP in controlling the symptoms of M\u00e9ni\u00e8re's disease. The 2\u00a0groups ended up without a difference in hearing level after ITI. According to these findings, administrating ITMP to control M\u00e9ni\u00e8re's disease seems to be less beneficial than ITG.<\/jats:p><\/jats:sec>","DOI":"10.1177\/0194599812472882","type":"journal-article","created":{"date-parts":[[2013,1,12]],"date-time":"2013-01-12T01:44:55Z","timestamp":1357955095000},"page":"642-647","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["The Effect of Intratympanic Methylprednisolone and Gentamicin Injection on M\u00e9ni\u00e8re's Disease"],"prefix":"10.1002","volume":"148","author":[{"given":"Nathalie","family":"Gabra","sequence":"first","affiliation":[{"name":"Division of Otolaryngology\u2013Head and Neck Surgery Montreal University Hospital Center University of Montreal Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Issam","family":"Saliba","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology\u2013Head and Neck 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