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Primary dependent variables were pure\u2010tone thresholds (pure\u2010tone average [PTA]), including \u201cnarrow\u201d PTA (0.5, 1, 2, 4\u00a0kHz), \u201cbroad\u201d PTA (0.5, 1, 2, 3, 4, 6, 8\u00a0kHz), low\u2010frequency PTA (0.25, 0.5, 1\u00a0kHz), and high\u2010frequency PTA (2, 3, 4, 6, 8\u00a0kHz). Repeated\u2010measures mixed regression modeling was used to assess the relationship between C\u2010reactive protein (CRP) and lipid levels with PTAs over time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In a cross\u2010sectional sample of 837 subjects, modest associations were found between triglycerides and all PTAs. Weak associations were observed between the ratio of total cholesterol and high\u2010density lipoprotein and narrow PTA, broad PTA, and high\u2010frequency PTA. However, when assessing changes in hearing and lipids over time in a longitudinal analysis, no significant associations between hearing and lipids remained. PTAs and CRP were not statistically associated when controlling for age and sex.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Associations between hearing and blood lipids have been the focus of scientific inquiry for more than 50 years. The current results suggest that the association is either spurious or too small to be of consequence in the assessment and treatment of hearing loss in older adults. Inquiry into other potential risk factors for age\u2010related hearing loss and associations with CVD may prove more fruitful.<\/jats:p><\/jats:sec>","DOI":"10.1177\/0194599812473936","type":"journal-article","created":{"date-parts":[[2013,1,16]],"date-time":"2013-01-16T01:03:44Z","timestamp":1358298224000},"page":"664-670","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Lipid and C\u2010reactive Protein Levels as Risk Factors for Hearing Loss in Older Adults"],"prefix":"10.1002","volume":"148","author":[{"given":"Annie N.","family":"Simpson","sequence":"first","affiliation":[{"name":"Department of Healthcare Leadership and Management Medical University of South Carolina Charleston South Carolina USA"},{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Medical University of South Carolina Charleston South Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lois 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