{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T21:48:52Z","timestamp":1767649732477,"version":"build-2065373602"},"reference-count":75,"publisher":"Wiley","issue":"S4","license":[{"start":{"date-parts":[[2013,3,27]],"date-time":"2013-03-27T00:00:00Z","timestamp":1364342400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Otitis media (OM) is the most common childhood bacterial infection and also the leading cause of conductive hearing loss in children. Currently, there is an urgent need for developing novel therapeutic agents for treating OM based on full understanding of molecular pathogenesis in the areas of molecular biology, biochemistry, genetics, and animal model studies in OM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To provide a state\u2010of\u2010the\u2010art review concerning recent advances in OM in the areas of molecular biology, biochemistry, genetics, and animal model studies and to discuss the future directions of OM studies in these areas.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Sources and Review Methods<\/jats:title><jats:p>A structured search of the current literature (since June 2007). The authors searched PubMed for published literature in the areas of molecular biology, biochemistry, genetics, and animal model studies in OM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Over the past 4 years, significant progress has been made in the areas of molecular biology, biochemistry, genetics, and animal model studies in OM. These studies brought new insights into our understanding of the molecular and biochemical mechanisms underlying the molecular pathogenesis of OM and helped identify novel therapeutic targets for OM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Implications for Practice<\/jats:title><jats:p>Our understanding of the molecular pathogenesis of OM has been significantly advanced, particularly in the areas of inflammation, innate immunity, mucus overproduction, mucosal hyperplasia, middle ear and inner ear interaction, genetics, genome sequencing, and animal model studies. Although these studies are still in their experimental stages, they help identify new potential therapeutic targets. Future preclinical and clinical studies will help to translate these exciting experimental research findings into clinical applications.<\/jats:p><\/jats:sec>","DOI":"10.1177\/0194599813479772","type":"journal-article","created":{"date-parts":[[2013,3,27]],"date-time":"2013-03-27T18:08:29Z","timestamp":1364407709000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Panel 4: Recent Advances in Otitis Media in Molecular Biology, Biochemistry, Genetics, and Animal Models"],"prefix":"10.1002","volume":"148","author":[{"given":"Jian\u2010Dong","family":"Li","sequence":"first","affiliation":[{"name":"Center for Inflammation, Immunity &amp; Infection Department of Biology Georgia State University Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann","family":"Hermansson","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Lund University Hospital Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allen F.","family":"Ryan","sequence":"additional","affiliation":[{"name":"Surgery\/Otolaryngology University of California San Diego La Jolla California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren O.","family":"Bakaletz","sequence":"additional","affiliation":[{"name":"Center for Microbial Pathogenesis The Research Institute at Nationwide Children's Hospital and Department of Pediatrics College of Medicine The Center for Microbial Interface Biology The Ohio State University Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steve D.","family":"Brown","sequence":"additional","affiliation":[{"name":"MRC Mammalian Genetics Unit MRC Harwell Harwell UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael T.","family":"Cheeseman","sequence":"additional","affiliation":[{"name":"MRC Mammalian Genetics Unit MRC Harwell Harwell UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven K.","family":"Juhn","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology University of Minnesota Medical School Minneapolis Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy T. 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